Evidence map›Paper›PMID 40244237›Full record

ArticleInternational journal of molecular sciences2025

Rescue of a Rotenone Model of Parkinson's Disease in

Silvia Romero-Sanz, Elena Caldero-Escudero, Pilar Álvarez-Illera, Jaime Santo-Domingo, Sergio de la Fuente, Paloma García-Casas, Rosalba I Fonteriz, Mayte Montero, Javier Álvarez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Silvia Romero-SanzDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain.ORCID 0000-0003-4671-7376
Elena Caldero-EscuderoDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain.ORCID 0009-0000-0694-3243
Pilar Álvarez-IlleraDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain.ORCID 0000-0003-4993-8705
Jaime Santo-DomingoDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain.ORCID 0000-0001-5501-0482
Sergio de la FuenteDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain.
Paloma García-CasasDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain.
Rosalba I FonterizDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain.ORCID 0000-0001-8349-6264
Mayte MonteroDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain.
Javier ÁlvarezDepartamento de Bioquímica y Biología Molecular y Fisiología, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain.ORCID 0000-0003-0636-5521

Funding

Ministerio de Ciencia, Innovación y Universidades ID2021-122239OB-I00
6 · The paper itself

Abstract

We have previously shown that the compound CGP37157, a mitochondrial Na

Indexed as

Caenorhabditis elegansMitochondriaParkinson DiseasePyrrolidinesRotenoneSodium-Calcium ExchangerAnimalsCaenorhabditis elegans ProteinsCalciumClonazepamDisease Models, AnimalDopaminergic NeuronsLongevityMembrane Potential, MitochondrialReactive Oxygen SpeciesThiazepinesCaenorhabditis elegans ProteinsCalciumCGP 37157ClonazepamPyrrolidinesReactive Oxygen SpeciesRotenoneSodium-Calcium ExchangerThiazepinesCa2+ signalingC. elegansCGP37157lifespanmitochondriaParkinson’s diseaserotenone

Identifiers

PMID40244237
PMCPMC11989483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.