Evidence map›Paper›PMID 40244201›Full record

ArticleInternational journal of molecular sciences2025

Potassium/Sodium Citrate Attenuates Paclitaxel-Induced Peripheral Neuropathy.

Daisuke Uta, Hideki Nakamura, Kengo Maruo, Kanoko Matsumura, Yohei Usami, Toshiaki Kume

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daisuke UtaDepartment of Applied Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-5644-1348
Hideki NakamuraDiscovery Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama 341-0005, Japan.ORCID 0009-0006-2817-1217
Kengo MaruoDiscovery Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama 341-0005, Japan.ORCID 0009-0005-4155-5728
Kanoko MatsumuraDiscovery Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama 341-0005, Japan.
Yohei UsamiDiscovery Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama 341-0005, Japan.
Toshiaki KumeDepartment of Applied Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.

Funding

JSPS KAKENHI 19K09323 and 22K09020Nippon Chemiphar Co., Ltd. No Number
6 · The paper itself

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a significant adverse event with unclear mechanisms and limited treatment alternatives. This study aimed to investigate the efficacy of two alkalizing agents, a mixture of potassium citrate and sodium citrate (K/Na citrate) or sodium bicarbonate (NaHCO

Indexed as

PaclitaxelPeripheral Nervous System DiseasesPotassium CitrateSodium CitrateAnimalsComplement C3aDisease Models, AnimalHyperalgesiaMaleRatsRats, Sprague-DawleyComplement C3aPaclitaxelPotassium CitrateSodium Citratealkalinizationelectrophysiologymechanical allodyniapaclitaxelpainpotassium/sodium citratespinal dorsal horn

Identifiers

PMID40244201
PMCPMC11989248

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.