Evidence map›Paper›PMID 40244085›Full record

ArticleChemistryOpen2025

Three-Component 1,2-Methylamidation of Alkynes via Coordinating Activation Strategy.

Jing Ren, Kaiyun Liu, Ning Wang, Jinlong Li, Xinyu Long, Chengming Li, Kaizhi Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing RenInstitute of BiopharmaceuticalsWest China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, P. R. China.
Kaiyun LiuInstitute of BiopharmaceuticalsWest China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, P. R. China.
Ning WangInstitute of BiopharmaceuticalsWest China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, P. R. China.
Jinlong LiInstitute of BiopharmaceuticalsWest China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, P. R. China.
Xinyu LongInstitute of BiopharmaceuticalsWest China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, P. R. China.
Chengming LiInstitute of Organ Transplantation, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, P. R. China.
Kaizhi LiInstitute of BiopharmaceuticalsWest China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, 610041, P. R. China.ORCID https://orcid.org/0000-0003-1358-620X

Funding

National Natural Science Foundation of China 22201190Natural Science Foundation of Sichuan Province 2023NSFSC1082Natural Science Foundation of Sichuan Province 2023NSFSC1088
6 · The paper itself

Abstract

The selective functionalization of carbon-carbon triple bonds with methyl groups remains a challenging task. Herein, the successful development of a novel copper-catalyzed three-component 1,2-methylamidation of carbon-carbon triple bond is reported. The readily available coupling partners, picolinamides and alkynes with dicumyl peroxide, serve as both the methyl source and oxidant in this difunctional strategy to access methylated enamides; the substrate scope is broad, demonstrating good functional group compatibility. The synthetic utility of the reaction is also demonstrated through the 1,2-methylamidation of alkynes via late-stage functionalization of substrates bearing biologically relevant molecules.

Indexed as

alkynesenamideslate‐stage functionalizationmethylamidationthree‐component

Identifiers

PMID40244085
PMCPMC12518046

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.