Evidence map›Paper›PMID 40244080›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2025

Engineering Magnetotactic Bacteria as Medical Microrobots.

Jiaqi Wang, Yi Xing, Michael Ngatio, Paulina Bies, Lu Lucy Xu, Liuxi Xing, Ahmed Zarea, Ashley V Makela, Christopher H Contag, Jinxing Li

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. CD4Sensors (Basel, Switzerland) · 2026
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Metabolic Gadolinium Labeling ofBiomaterials research · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Engineering Magnetotactic Bacteria as Medical Microrobots.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiaqi WangDepartment of Biomedical Engineering, and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Yi XingDepartment of Biomedical Engineering, and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Michael NgatioDepartment of Biomedical Engineering, and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Paulina BiesDepartment of Biomedical Engineering, and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Lu Lucy XuDepartment of Biomedical Engineering, and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Liuxi XingDepartment of Biomedical Engineering, and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Ahmed ZareaDepartment of Biomedical Engineering, and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Ashley V MakelaDepartment of Biomedical Engineering, and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Christopher H ContagDepartment of Biomedical Engineering, and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Jinxing LiDepartment of Biomedical Engineering, and Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, MI, 48824, USA.ORCID https://orcid.org/0000-0002-5888-342X

Funding

Magnetic Microrobots Assist AAV4 for CFTR Gene Delivery Through Mucus BarrierR21EB037346 · NIBIB · MICHIGAN STATE UNIVERSITY · PI JINXING Li · 2025 to 2026
$447k
National Science Foundation CMMI-2323917National Science Foundation ECCS-2216131National Science Foundation ECCS-2334134National Science Foundation ECCS-2339495National Science Foundation EFMA-2318057NIBIB NIH HHS R21 EB037346
6 · The paper itself

Abstract

Nature's ability to create complex and functionalized organisms has long inspired engineers and scientists to develop increasingly advanced machines. Magnetotactic bacteria (MTB), a group of Gram-negative prokaryotes that biomineralize iron and thrive in aquatic environments, have garnered significant attention from the bioengineering community. These bacteria possess chains of magnetic nanocrystals known as magnetosomes, which allow them to align with Earth's geomagnetic field and navigate through aquatic environments via magnetotaxis, enabling localization to areas rich in nutrients and optimal oxygen concentration. Their built-in magnetic components, along with their intrinsic and/or modified biological functions, make them one of the most promising platforms for future medical microrobots. Leveraging an externally applied magnetic field, the motion of MTBs can be precisely controlled, rendering them suitable for use as a new type of biohybrid microrobotics with great promise in medicine for bioimaging, drug delivery, cancer therapy, antimicrobial treatment, and detoxification. This mini-review provides an up-to-date overview of recent advancements in MTB microrobots, delineates the interaction between MTB microrobots and magnetic fields, elucidates propulsion mechanisms and motion control, and reports state-of-the-art strategies for modifying and functionalizing MTB for medical applications.

Indexed as

BacteriaBioengineeringMagnetosomesRoboticsHumansMagnetic Fieldsbioimagingcancer therapydrug deliverymagnetotactic bacteriamicrorobotics

Identifiers

PMID40244080
PMCPMC12243727

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.