Evidence map›Paper›PMID 40244045›Full record

ArticleInternational journal of molecular sciences2025

Tri-Phenyl-Phosphonium-Based Nano Vesicles: A New In Vitro Nanomolar-Active Weapon to Eradicate PLX-Resistant Melanoma Cells.

Silvana Alfei, Carola Torazza, Francesca Bacchetti, Maria Grazia Signorello, Mario Passalacqua, Cinzia Domenicotti, Barbara Marengo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Efficacy of phosphonium amphiphilic salts against Acanthamoeba genotype T4.International journal for parasitology. Drugs and drug resistance · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Silvana AlfeiDepartment of Pharmacy, University of Genoa, Viale Cembrano, 16148 Genoa, Italy.ORCID 0000-0002-4630-4371
Carola TorazzaDepartment of Pharmacy, University of Genoa, Viale Cembrano, 16148 Genoa, Italy.ORCID 0000-0003-2236-5142
Francesca BacchettiDepartment of Pharmacy, University of Genoa, Viale Cembrano, 16148 Genoa, Italy.ORCID 0009-0002-0686-7062
Maria Grazia SignorelloBiochemistry Laboratory, Department of Pharmacy, University of Genoa, Viale Benedetto XV 3, 16132 Genova, Italy.
Mario PassalacquaBiochemistry Section, Department of Experimental Medicine (DIMES), University of Genova, Via Alberti L.B., 16132 Genoa, Italy.ORCID 0000-0003-2779-6259
Cinzia DomenicottiCentro 3R, Department of Information Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy.ORCID 0000-0002-5003-7333
Barbara MarengoCentro 3R, Department of Information Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy.ORCID 0000-0003-3056-6569

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous metastatic melanoma (CMM) is the most aggressive form of skin cancer, with characteristics including a poor prognosis, chemotherapy-induced secondary tumorigenesis, and the emergence of drug resistance. Our recent study demonstrated that triphenyl phosphonium (TPP)-based nanovesicles (BPPB), which have amphiphilic properties, exert potent ROS-dependent anticancer effect against PLX4032 (PLX)-sensitive MeOV BRAF

Indexed as

Antineoplastic AgentsDrug Resistance, NeoplasmMelanomaNanoparticlesOrganophosphorus CompoundsSkin NeoplasmsVemurafenibCell Line, TumorCell ProliferationCell SurvivalHumansProto-Oncogene Proteins B-rafReactive Oxygen SpeciesAntineoplastic AgentsOrganophosphorus CompoundsProto-Oncogene Proteins B-rafReactive Oxygen SpeciesVemurafenibcell viability (%) studiescutaneous metastatic melanoma (CMM)low cytotoxicity on HaCaT cellslow hemolytic effectsnanosized bola-amphiphiles vesiclestriphenyl phosphonium (TPP) groups

Identifiers

PMID40244045
PMCPMC11990052

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.