ArticleInternational journal of molecular sciences2025
Transcription Factor p73 Is a Predictor of Platinum Resistance and Promotes Aggressive Epithelial Ovarian Cancers.
Ahmed Shoqafi, Reem Ali, Ayat Lashen, Jennie N Jeyapalan, Asmaa Ibrahim, Michael S Toss, Emad A Rakha, Mashael Algethami, Shatha Alqahtani, Nigel P Mongan and 2 more
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In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Ahmed ShoqafiNaaz Coker Ovarian Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham NG7 3RD, UK.ORCID 0009-0005-7034-126X Reem AliDivision of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha P.O. Box 34110, Qatar.ORCID 0000-0003-2210-4241 Ayat LashenNaaz Coker Ovarian Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham NG7 3RD, UK.
Jennie N JeyapalanNaaz Coker Ovarian Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham NG7 3RD, UK.ORCID 0000-0002-6133-224X Asmaa IbrahimDepartment of Pathology, Nottingham University Hospitals, City Hospital Campus, Nottingham NG5 1PB, UK.
Michael S TossDepartment of Pathology, Nottingham University Hospitals, City Hospital Campus, Nottingham NG5 1PB, UK.
Emad A RakhaNaaz Coker Ovarian Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham NG7 3RD, UK.ORCID 0000-0002-5009-5525 Mashael AlgethamiNaaz Coker Ovarian Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham NG7 3RD, UK.
Shatha AlqahtaniNaaz Coker Ovarian Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham NG7 3RD, UK.ORCID 0009-0000-9283-1546 Nigel P MonganNaaz Coker Ovarian Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham NG7 3RD, UK.
Dindial RamotarDivision of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha P.O. Box 34110, Qatar.
Srinivasan MadhusudanNaaz Coker Ovarian Cancer Research Centre, Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham NG7 3RD, UK.ORCID 0000-0002-5354-5480 Funding
Naaz Coker Ovarian Cancer Research Centre grant number UoN 17072457
6 · The paper itselfAbstract
Resistance to platinum-based chemotherapy is a major clinical problem in ovarian cancers. The development of predictive biomarkers and therapeutic approaches is an area of unmet need. p73, a member of the p53 family of transcription factors, has essential functions during DNA repair, proliferation, invasion, and apoptosis. The role of p73 in ovarian cancer pathogenesis and response to therapy is largely unknown. The clinicopathological significance of p73 protein expression was evaluated in 278 human ovarian cancers.
Indexed as
Carcinoma, Ovarian EpithelialDrug Resistance, NeoplasmOvarian NeoplasmsPlatinumTumor Protein p73Antineoplastic AgentsApoptosisBiomarkers, TumorCell Line, TumorCell ProliferationCisplatinFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedAntineoplastic AgentsBiomarkers, TumorCisplatinPlatinumTP73 protein, humanTumor Protein p73biomarkerDNA repairovarian cancersp53p73platinum resistance
Identifiers
PMID40244040
PMCPMC11989448
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