Evidence map›Paper›PMID 40244025›Full record

ArticleInternational journal of molecular sciences2025

The Use of Potent Populations of Expanded Fetal Human Placental Stromal Cells for the Treatment of Dextran Sodium Sulfate-Induced Colitis in a Mouse Model.

Raphael Gorodetsky, Astar Lazmi Hailu, Evgenia Volinsky, Boaz Adani, Orit Pappo, Eran Israeli

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raphael GorodetskyLaboratory of Biotechnology and Radiobiology, Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.
Astar Lazmi HailuLaboratory of Biotechnology and Radiobiology, Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.
Evgenia VolinskyLaboratory of Biotechnology and Radiobiology, Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.
Boaz AdaniLaboratory of Biotechnology and Radiobiology, Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.
Orit PappoDepartment of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.
Eran IsraeliDepartment of Gastroenterology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.ORCID 0000-0001-8679-4363

Funding

Israel Science Foundation (ISF# 1639/14)
6 · The paper itself

Abstract

Inflammatory Bowel Disease (IBD) is a multifactorial gastrointestinal condition encompassing two major forms of intestinal inflammation: Crohn's disease (CD) and ulcerative colitis (UC). Both conditions are linked to auto-inflammatory reactions and genetic predispositions. Various drug therapies and biological treatments proposed to reduce IBD-associated inflammation. We induced IBD in a mouse model by stimulating bowel inflammation with an oral dextran sodium sulfate (DSS) beverage. Our novel cell therapy approach for IBD involves intramuscular (IM) and intraperitoneal (IP) delivery of non-matched, expanded, potent xenogeneic fetal human mesenchymal stromal cells (f-hPSCs) in 2 × 10

Indexed as

ColitisMesenchymal Stem CellsMesenchymal Stem Cell TransplantationPlacentaAnimalsDextran SulfateDisease Models, AnimalFemaleHumansInflammatory Bowel DiseasesMicePregnancyDextran Sulfateadult cell therapyC3H mouse modelcell therapyexpanded fetal human placental stromal cells (f-hPSCs)inflammatory bowel disease (IBD)

Identifiers

PMID40244025
PMCPMC11989926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.