Evidence map›Paper›PMID 40244003›Full record

ArticleInternational journal of molecular sciences2025

Investigation of Anti-Cancer Properties of Novel Curcuminoids in Leukemic Cells and Dalton Lymphoma Ascites Model.

Vijayalakshmi Sudarshan, P Shyamjith, Sujeet Kumar, Febina Ravindran, Bibha Choudhary, Subhas S Karki

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vijayalakshmi SudarshanDepartment of Pharmaceutical Chemistry, Dr. Prabhakar B Kore Basic Science Research Centre, Off-Campus, KLE College of Pharmacy (A Constituent Unit of KAHER-Belagavi), Bengaluru 560010, India.
P ShyamjithInstitute of Bioinformatics and Applied Biotechnology, Electronic City Phase 1, Bengaluru 560100, India.ORCID 0009-0004-9646-763X
Sujeet KumarDepartment of Pharmaceutical Chemistry, NITTE College of Pharmaceutical Sciences (A Constituent College of Nitte Deemed to Be University, Mangaluru), Bengaluru, 560064, India.ORCID 0000-0002-0833-158X
Febina RavindranInstitute of Bioinformatics and Applied Biotechnology, Electronic City Phase 1, Bengaluru 560100, India.ORCID 0000-0001-6441-4059
Bibha ChoudharyInstitute of Bioinformatics and Applied Biotechnology, Electronic City Phase 1, Bengaluru 560100, India.
Subhas S KarkiDepartment of Pharmaceutical Chemistry, Dr. Prabhakar B Kore Basic Science Research Centre, Off-Campus, KLE College of Pharmacy (A Constituent Unit of KAHER-Belagavi), Bengaluru 560010, India.ORCID 0000-0002-5599-3594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukemia, one of the major causes of cancer death, ranks 11th worldwide among cancer-related deaths. The current treatment of leukemia faces challenges recently due to a high burden of side effects. It is well established that curcumin has anticancer and tumor-suppressing activities in several cancers in addition to leukemia. Accordingly, 15 derivatives were designed and prepared to improve the shortcomings of curcumin, such as poor aqueous solubility, chemical instability, and low bioavailability. All 15 were evaluated for cytotoxicity against the leukemic cell line MOLT-4, which led to the prioritization and further evaluation of compound curcuminoid (2

Indexed as

Antineoplastic AgentsAscitesCurcuminDiarylheptanoidsLeukemiaLymphomaAnimalsApoptosisCell Line, TumorCell ProliferationDisease Models, AnimalHumansMembrane Potential, MitochondrialMiceMitochondriaReactive Oxygen SpeciesAntineoplastic AgentsCurcuminDiarylheptanoidsReactive Oxygen Speciesapoptosiscurcuminoidscyclopentanone derivativescytotoxicityleukaemiamonoketone

Identifiers

PMID40244003
PMCPMC11989719

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.