Evidence map›Paper›PMID 40243990›Full record

ArticleInternational journal of molecular sciences2025

Novel Compounds Target Aberrant Calcium Signaling in the Treatment of Relapsed High-Risk Neuroblastoma.

Dana-Lynn T Koomoa, Nathan Sunada, Italo Espinoza-Fuenzalida, Dustin Tacdol, Madeleine Shackleford, Li Feng, Dianqing Sun, Ingo Lange

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dana-Lynn T KoomoaCollege of Pharmacy and Health Sciences, Western New England University, Springfield, MA 01119, USA.
Nathan SunadaCollege of Pharmacy and Health Sciences, Western New England University, Springfield, MA 01119, USA.
Italo Espinoza-FuenzalidaThe Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720, USA.
Dustin TacdolThe Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720, USA.
Madeleine ShacklefordThe Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720, USA.ORCID 0000-0003-2599-1747
Li FengThe Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720, USA.
Dianqing SunThe Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720, USA.ORCID 0000-0001-7330-1742
Ingo LangeCollege of Pharmacy and Health Sciences, Western New England University, Springfield, MA 01119, USA.

Funding

Manipulating Aberrant Calcium Signaling to Target Relapsed High-Risk NeuroblastomaR15CA277188 · NCI · WESTERN NEW ENGLAND UNIVERSITY · PI KOOMOA, DANA-LYNN TAKEKO · 2024 to 2024
$424k
NCI NIH HHS R15 CA277188NIH HHS 1R15CA277188-24A1the Hawaii Community Foundation -Victoria S. and Bradley L. Geist Foundation Medical Research grant 20CON-106812
6 · The paper itself

Abstract

High-risk neuroblastoma (HRNB) is an extracranial solid pediatric cancer. Despite the plethora of treatments available for HRNB, up to 65% of patients are refractory or exhibit an initial response to treatment that transitions to therapy-resistant relapse, which is invariably fatal. A key feature that promotes HRNB progression is aberrant calcium (Ca

Indexed as

Antineoplastic AgentsCalcium SignalingNeuroblastomaCalciumCalcium ChannelsCell Line, TumorEndoplasmic ReticulumHumansMitochondriaNeoplasm Recurrence, LocalAntineoplastic AgentsCalciumCalcium Channelsapoptosiscalcium release-activated calcium (CRAC) current (ICRAC)chemoresistanceendoplasmic reticulumhigh-risk neuroblastomamitochondriaMYCNp53proliferationstore-operated calcium entry (SOCE)

Identifiers

PMID40243990
PMCPMC11989759

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.