Evidence map›Paper›PMID 40243957›Full record

ArticleJACC. Basic to translational science2025

Oversized Conduits Predict Stenosis in Tissue Engineered Vascular Grafts.

Kevin M Blum, Mackenzie E Turner, Erica L Schwarz, Cameron A Best, John M Kelly, Andrew R Yates, Kan N Hor, Yuichi Matsuzaki, Joseph D Drews, Jason Zakko and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Small Diameter Vascular Grafts Made in Minutes.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kevin M BlumCenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Mackenzie E TurnerCenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Molecular, Cellular, and Developmental Biology, The Ohio State University, Columbus, Ohio, USA; Biomedical Sciences Graduate Program, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Erica L SchwarzDepartment of Pediatrics and Bioengineering, Stanford University, Stanford, California, USA; Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Cameron A BestCenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
John M KellyCenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Pediatric Cardiology, Nationwide Children's Hospital, Columbus, Ohio, USA.
Andrew R YatesDepartment of Pediatric Cardiology, Nationwide Children's Hospital, Columbus, Ohio, USA.
Kan N HorDepartment of Pediatric Cardiology, Nationwide Children's Hospital, Columbus, Ohio, USA.
Yuichi MatsuzakiCenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
Joseph D DrewsCenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Jason ZakkoCenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Kejal ShahCenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Toshiharu ShinokaCenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA.
Jay D HumphreyDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Alison L MarsdenDepartment of Pediatrics and Bioengineering, Stanford University, Stanford, California, USA.
Christopher K BreuerCenter for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA. Electronic address: Christopher.Breuer@nationwidechildrens.org.

Funding

A Study Evaluating the Safety and Efficacy of Second-Generation Tissue Engineered Vascular Grafts (TEVG2)UH3HL148693 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI christopher Kane breuer · 2021 to 2026
$3.0M
NHLBI NIH HHS UH3 HL148693
6 · The paper itself

Abstract

Tissue-engineered vascular grafts (TEVGs) offer promising advancements in treating congenital heart disease by enabling the creation of autologous tissue for complex cardiac repairs. Our approach involves implanting biodegradable scaffolds seeded with autologous cells that remodel into functional neovessels. To understand better the factors guiding neovessel formation, we evaluated 50 ovine thoracic TEVGs using angiography at 1 and 6 weeks postimplantation. Nondimensionalization accounted for anatomical differences between animals and identified hemodynamics and surgical sizing as potential driving factors. Regression analysis revealed that narrowing at the inflow anastomosis and graft oversizing correlated significantly with stenosis development. Computational fluid dynamics showed that these factors influenced wall shear stress and flow patterns, contributing to neovessel narrowing. Comparisons with clinical trial data from Fontan conduits supported these findings, emphasizing that matching graft size to the native inflow vessel can reduce stenosis and enhance TEVG performance.

Indexed as

computational fluid dynamicsoversizingstenosistissue engineered vascular graft

Identifiers

PMID40243957
PMCPMC12434202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.