Evidence map›Paper›PMID 40243953›Full record

ArticleInternational journal of molecular sciences2025

Novel 5-Oxopyrrolidine-3-carbohydrazides as Potent Protein Kinase Inhibitors: Synthesis, Anticancer Evaluation, and Molecular Modeling.

Ingrida Tumosienė, Maryna Stasevych, Viktor Zvarych, Ilona Jonuškienė, Kristina Kantminienė, Vilma Petrikaitė

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ingrida TumosienėDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų Pl. 19, 50254 Kaunas, Lithuania.ORCID 0000-0003-0357-2170
Maryna StasevychDepartment of Technology of Biologically Active Substances, Pharmacy, and Biotechnology, Lviv Polytechnic National University, S. Bandera Str. 12, 79013 Lviv, Ukraine.ORCID 0000-0001-5042-4133
Viktor ZvarychDepartment of Automated Control Systems, Lviv Polytechnic National University, S. Bandera Str. 12, 79013 Lviv, Ukraine.ORCID 0000-0003-3036-0050
Ilona JonuškienėDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų Pl. 19, 50254 Kaunas, Lithuania.ORCID 0000-0002-6865-6888
Kristina KantminienėDepartment of Physical and Inorganic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, 50254 Kaunas, Lithuania.ORCID 0000-0002-0266-8608
Vilma PetrikaitėLaboratory of Drug Targets Histopathology, Institute of Cardiology, Lithuanian University of Health Sciences, Sukilėlių Pr. 13, 50162 Kaunas, Lithuania.ORCID 0000-0002-4106-5535

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel hydrazones bearing diphenylamine and 5-oxopyrrolidine moieties, along with benzene and naphthalene rings substituted with hydroxy, alkoxy, or carboxylic groups, were synthesized. Their anticancer activity was evaluated in vitro using both 2D (MTT and 'wound healing' assays) and 3D (cell spheroid) models against human melanoma IGR39 cells, the triple-negative breast cancer cell line MDA-MB-231, and pancreatic carcinoma Panc-1 cell line. Compounds

Indexed as

Antineoplastic AgentsHydrazinesHydrazonesProtein Kinase InhibitorsCell Line, TumorCell MovementCell ProliferationCell SurvivalHumansModels, MolecularMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentscarbohydrazideHydrazinesHydrazonesProtein Kinase Inhibitors3D cell culturesdiphenylaminehydrazonemelanomamigrationpancreatic tumortriple-negative breast cancer

Identifiers

PMID40243953
PMCPMC11989890

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.