SynthesisAndrology2026
The role and implication of platelet-rich plasma in male factor infertility: A systematic review of human studies.
Synthesis in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role and implication of platelet-rich plasma in male factor infertility: A systematic review of human studies.Andrology · 2026Pooled it
- The Effect of Intratesticular Platelet-Rich Plasma Injection on Sperm Retrieval Rates in Non-Obstructive Azoospermia Male after Failed Testicular Sperm Extraction: An Inception Cohort.The world journal of men's health · 2026Article
- Differential Tissue Responses to Papaverine and Platelet Rich Plasma in Testicular Torsion: Evidence From a Controlled Rat I/R Model.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Effects of Platelet-Rich Plasma Dose and Application Strategy on Post-Thaw Spermatological Parameters in Goat Semen.Veterinary sciences · 2026Article
- Evaluation of the Effect of Platelet-Rich Fibrin (PRF) Protocol and Laser Acupuncture in the Treatment of Infertile Men with Non-Obstructive Azoospermia: A Randomized Clinical Trial.Journal of lasers in medical sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCryopreservation causes sperm injury and the success of surgical sperm retrieval (SSR) for azoospermic men is just over half depending on the cause of azoospermia. The role of autologous platelet-rich plasma (PRP) in male factor infertility (MFI) is unclear.
objectiveTo conduct a systematic review of the role of PRP in MFI focusing on human studies.
methodsA systematic review was conducted using PubMed with reference to the PRISMA 2020 statement. The risk of bias assessment of the included studies was performed using the JBI assessment checklists. Outcome measures included the effects of PRP on cryopreservation, semen parameters, and SSR.
resultsThe search retrieved 119 articles and 10 met the pre-defined PICO criteria. These included 7 prospective studies, 1 randomised-controlled study, 1 retrospective study, and 1 case report. PRP appeared to improve semen parameters, decrease DNA fragmentation, improve recovery of cryopreserved sperm, and improve SSR rate. A case report demonstrated successful intracytoplasmic sperm injection and pregnancy following incubation of semen with PRP in a patient with previous failed IVF attempts. DISCUSSION AND
conclusionThis is the first systematic review summarising data from human studies on the role of PRP in MFI. The inclusion criteria and outcomes of across studies varied, limiting the ability to conduct a quantitative analysis. Data from early studies on PRP in MFI are promising. However, there is a lack of well-designed clinical studies on this topic, and further research is needed to replicate current findings and evaluate the potential benefits of PRP in MFI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.