Salivary Interleukin-6 and Interleukin-18 Levels and Their Association with Dental Health in Children with Idiopathic Nephrotic Syndrome.

Paula Piekoszewska-Ziętek, Natalia Korytowska-Przybylska, Małgorzata Pańczyk-Tomaszewska, Dorota Olczak-Kowalczyk

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paula Piekoszewska-ZiętekDepartment of Pediatric Dentistry, Medical University of Warsaw, 02-091 Warsaw, Poland.

Natalia Korytowska-PrzybylskaDepartment of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Medical University of Warsaw, 02-091 Warsaw, Poland.

Małgorzata Pańczyk-TomaszewskaDepartment of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.ORCID 0000-0002-4566-7074

Dorota Olczak-KowalczykDepartment of Pediatric Dentistry, Medical University of Warsaw, 02-091 Warsaw, Poland.

Funding

Medical University of Warsaw WLS3/1/M/MB/N/23

6 · The paper itself

Abstract

Idiopathic nephrotic syndrome (NS) is associated with immune dysfunction and increased susceptibility to infections. Oral health may influence systemic inflammation and disease progression. This study aimed to evaluate the salivary levels of interleukin-6 (IL-6) and interleukin-18 (IL-18) in children with NS and their association with dental health, particularly caries prevalence and the consequences of untreated caries. A cross-sectional study was conducted on 86 children aged 5-17 years, including 40 NS patients and 46 healthy controls. Clinical dental examinations assessed caries prevalence using the dmft/DMFT index and the impact of untreated caries using the pufa/PUFA index. Unstimulated saliva samples were collected, and IL-6 and IL-18 concentrations were measured using enzyme-linked immunosorbent assay. NS patients exhibited a significantly lower prevalence of active carious lesions than controls (50% vs. 72%,

Indexed as

Dental CariesInterleukin-18Interleukin-6Nephrotic SyndromeOral HealthSalivaAdolescentCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesFemaleHumansMaleIL18 protein, humanIL6 protein, humanInterleukin-18Interleukin-6cariesinterleukin 18interleukin 6nephrotic syndromeoral diseases

Identifiers

PMID40243946

DOI10.3390/ijms26073175

PMCPMC11989940

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.