Evidence map›Paper›PMID 40243929›Full record

ArticleInternational journal of molecular sciences2025

Protective Vaccination of Mice Against Blood-Stage Malaria Impacts Hepatic Expression of Genes Encoding Acute-Phase Proteins and IL-6 Family Members.

Frank Wunderlich, Daniela Gerovska, Denis Delic, Marcos J Araúzo-Bravo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. SAA4: An Underdog Within the Serum Amyloid a Superfamily?International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Frank WunderlichDepartment of Biology, Heinrich-Heine-University, 40225 Düsseldorf, Germany.
Daniela GerovskaComputational Biology and Systems Biomedicine, Biogipuzkoa Health Research Institute, 20014 San Sebastian, Spain.ORCID 0000-0003-0671-4277
Denis DelicBoehringer Ingelheim Pharma & Co., KG, 88400 Biberach, Germany.
Marcos J Araúzo-BravoComputational Biology and Systems Biomedicine, Biogipuzkoa Health Research Institute, 20014 San Sebastian, Spain.ORCID 0000-0002-3264-464X

Funding

European Union's Horizon 2020 research and innovation programme ERAPERMED2022-245Instituto de Salud Carlos III of Spain, Infrastructure of Precision Medicine associated with Science and Technology (IMPaCT) of the Strategic Action in Health iDATA-MPMinisterio de Ciencia e Innovación, Spain PID2023-152752OB-I00/AEI/10.13039/501100011033
6 · The paper itself

Abstract

In response to vaccination and/or infectious agents, the liver produces acute-phase proteins (APPs) driven by IL-6, which circulate in blood plasma as components of the humoral innate defense. This study investigates the liver of mice for possible effects of protective vaccination against primary blood-stage infections of

Indexed as

Acute-Phase ProteinsInterleukin-6LiverMalariaMalaria VaccinesAnimalsFemaleGene Expression RegulationMiceMice, Inbred BALB CPlasmodium chabaudiVaccinationAcute-Phase ProteinsInterleukin-6Malaria Vaccinesblood-stage malariacoagulationcomplementfibrinolysisgenes expressing plasma proteinsIL-6 trans-signalingliver responseprotective vaccination

Identifiers

PMID40243929
PMCPMC11989154

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.