Evidence map›Paper›PMID 40243885›Full record

ArticleInternational journal of molecular sciences2025

Longitudinal Analysis of Placental

Ariadna Gómez-Vilarrubla, Maria Niubó-Pallàs, Berta Mas-Parés, Alexandra Bonmatí-Santané, Jose-Maria Martínez-Calcerrada, Beatriz López, Aaron Peñas-Cruz, Francis de Zegher, Lourdes Ibáñez, Abel López-Bermejo and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ariadna Gómez-VilarrublaMaternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), 17190 Salt, Spain.ORCID 0000-0001-8183-5218
Maria Niubó-PallàsMaternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), 17190 Salt, Spain.ORCID 0009-0001-2331-0218
Berta Mas-ParésPediatric Endocrinology Research Group, Girona Institute for Biomedical Research (IDIBGI), 17190 Salt, Spain.ORCID 0000-0001-8283-3089
Alexandra Bonmatí-SantanéMaternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), 17190 Salt, Spain.ORCID 0000-0002-4354-7773
Jose-Maria Martínez-CalcerradaMaternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), 17190 Salt, Spain.
Beatriz LópezControl Engineering and Intelligent Systems (eXiT), University of Girona, 17003 Girona, Spain.ORCID 0000-0001-9210-0073
Aaron Peñas-CruzPediatric Endocrinology Research Group, Girona Institute for Biomedical Research (IDIBGI), 17190 Salt, Spain.
Francis de ZegherDepartment of Development and Regeneration, University of Leuven, 3000 Leuven, Belgium.
Lourdes IbáñezEndocrinology, Pediatric Research Institute, Sant Joan de Déu Children's Hospital, 08950 Esplugues de Llobregat, Spain.ORCID 0000-0003-4595-7191
Abel López-BermejoPediatric Endocrinology Research Group, Girona Institute for Biomedical Research (IDIBGI), 17190 Salt, Spain.
Judit BassolsMaternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), 17190 Salt, Spain.ORCID 0000-0001-8821-6655

Funding

Instituto de Salud Carlos III PI20/00399Instituto de Salud Carlos III PI23/00545
6 · The paper itself

Abstract

Accumulating evidence suggests that the predisposition to metabolic diseases is established in utero through epigenomic modifications. However, it remains unclear whether childhood obesity results from preexisting epigenomic alterations or whether obesity itself induces changes in the epigenome. This study aimed to identify DNA methylation marks in the placenta associated with obesity-related outcomes in children at age 6 and to assess these marks in blood samples at age 6 and whether they correlate with obesity-related outcomes at that time. Using an epigenome-wide DNA methylation microarray on 24 placental samples, we identified differentially methylated CpGs (DMCs) associated with offspring BMI-SDS at 6 years. Individual DMCs were validated in 147 additional placental and leukocyte samples from children at 6 years of age. The methylation and/or gene expression of

Indexed as

DNA MethylationInsulin Receptor Substrate ProteinsPediatric ObesityPlacentaChildCpG IslandsEpigenesis, GeneticFemaleHumansLongitudinal StudiesMalePregnancyInsulin Receptor Substrate ProteinsIRS1 protein, humanchildhood obesityDNA methylationfetal programmingleukocytesmetabolic riskplacenta

Identifiers

PMID40243885
PMCPMC11988732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.