ArticleBrazilian dental journal2025
Cytotoxicity and bioactivity of CIMMO DTA restorative cement in human activated-dental pulp cells in vitro.
Article in Brazilian dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Can angiotensin II affect the inflammatory response of human dental pulp cells in vitro?Journal of applied oral science : revista FOB · 2026Article
- Photobiomodulation associated to a 58S bioactive glass for dentin hypersensitivity treatment - an in vitro study on differentiation of human dental pulp cells.Lasers in medical science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioceramic materials have been introduced in dentistry due to their physical, chemical, and biological properties, which are considered advanced in clinical practice. According to the manufacturer, CIMMO DTA bioceramic restorative cement is a biological bioceramic cement and was introduced recently at a low cost compared to other bioceramic materials. However, no studies evaluated the effect of CIMMO DTA on human dental pulp cells (HDPC) activated with lipopolysaccharide (LPS). Therefore, this study aimed to evaluate the cytotoxicity and the osteo/odontogenic differentiation potential in HDPC activated with LPS exposed to CIMMO DTA compared to Hydro-C. HDPC activated or not with LPS were cultured, plated, and exposed to different dilutions of CIMMO DTA and Hydro-C extracts. At 24h, 48h, and 72h, the cells were subjected to the MTT assay. The osteo/odontogenic mineralization potential of cells was evaluated through the Alizarin red S staining assay at a 21-day time point. Statistical analysis was performed using a two-way analysis of variance (ANOVA) followed by Tukey's post-test (p<0.05). In general, the tested materials unaffected the metabolic activity and viability of cells in all dilutions evaluated. The CIMMO DTA reduced the osteo/odontogenic differentiation potential of the HDPC according to qualitative and quantitative results at dilutions of 1:8. Therefore, the results of the present study suggested that CIMMO DTA presents limited bioactive potential on HDPC in vitro.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.