ArticleMemorias do Instituto Oswaldo Cruz2025
Pandemic ST131 Escherichia coli presenting the UPEC/EAEC and ExPEC/EAEC hybrid pathotypes recovered from extraintestinal infections in a clinical setting of the Brazilian Amazon region.
Article in Memorias do Instituto Oswaldo Cruz, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Development and clinical validation of a CRISPR/Cas9-engineered reporter phage cocktail for rapid detection ofMicrobiology spectrum · 2026Article
- Phylogenetic analysis and characterization of hybrid enteroaggregative/uropathogenic Escherichia coli strains isolated from urinary tract infection.Molecular biology reports · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEscherichia coli is a commensal organism but may become pathogenic by the acquisition of virulence factors involved with intestinal (IPEC) or extraintestinal (ExPEC) infections. Some strains, known as hybrids, may harbour virulence determinants of both IPEC and ExPEC pathotypes, increasing their virulence potential. Reports of hybrid E. coli in Brazil are rare, and the associated lineages were poorly explored.
objectivesThis study characterised ExPEC E. coli strains focusing on the occurrence of hybrid pathotypes.
methodsFifteen clinical ExPEC strains were submitted to multilocus sequence typing (MLST), susceptibility test, and polymerase chain reaction (PCR) targeting IEC/ExPEC virulence markers.
findingsAll strains were multidrug-resistant, and 11 STs were determined among the 15 ExPEC strains, including local/new and pandemic lineages, such as ST69 and ST131. Twelve/15 isolates were classified as hybrids, due to the presence of virulence markers of both Enteroaggregative E. coli (EAEC) and ExPEC or UPEC pathotypes. These UPEC/EAEC (n = 10) and ExPEC/EAEC (n = 2) hybrid strains were found among distinct phylogroups and lineages, including new STs. Interestingly, most hybrids belonged to the pandemic ST131 lineage, and this genotype had never been previously reported in the ST131 circulating in Brazil. MAIN
conclusionsTherefore, this study provides new information on the epidemiological scenario of hybrid E. coli, contributing to a better understanding of the occurrence and pathogenic potential of these organisms.
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