SynthesisCadernos de saude publica2025
Pesticide exposure and the development of Parkinson disease: a systematic review of Brazilian studies.
Synthesis in Cadernos de saude publica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Environmental determinants of Parkinson's disease and attributable burden in Latin America.Research square · 2026Article
- Advances in the neurotoxicity of ecological pesticide maneb: mechanisms and implications for human health.Frontiers in public health · 2026Review
- Carcinogenic effects of long-term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague-Dawley rats.Environmental health : a global access science source · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson disease is the second most prevalent neurodegenerative disease globally. Parkinson disease etiology is not fully understood, it is believed to be a multifactorial disease. Pesticide exposure is highlighted among the factors. Thus, this study analyzed the relationship between pesticide exposure and the development of Parkinson disease in Brazil via a systematic review. The review was conducted following the PRISMA methodology and PICOS process, using the PubMed, Web of Science, and Virtual Health Library databases. Inclusion criteria were observational studies, conducted in humans, focusing on the Brazilian population, and investigating the relationship between pesticide exposure and Parkinson disease development. Studies quality was evaluated using the Hawker checklist. A total of 85 publications were identified for eligibility and 12 studies were included in the qualitative synthesis. Regarding study quality, two showed poor, nine moderate, and only one presented high quality. Moreover, 11 studies indicated an association between pesticide exposure and increased occurrence of Parkinson disease in Brazilian people. Additionally, such association was more prevalent in the presence of the following factors: (i) single-nucleotide polymorphism IVS1-7 A→G of PINK1; (ii) variations in the gene and protein expressions of the enzyme glutathione S-transferase; (iii) occupational exposure; (iv) living in a non-urban area; (v) low schooling level, and (iv) being male. This study is the first to infer, via the systematization of observational studies conducted with the Brazilian population, the association between pesticide exposure and the occurrence of Parkinson disease in the country, evidencing the necessity of efficient public policies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.