Evidence map›Paper›PMID 40243780›Full record

ArticleInternational journal of molecular sciences2025

Expression of Fascin and DNA Topoisomerase 2-Alpha in Breast Carcinoma: Correlation with Histological Subtypes and Other Prognostic Markers.

Alberto Sánchez-Espinosa, José García-Rodríguez, Virginia Alonso-Aguirre, Jesús María Acosta-Ortega, Pablo Conesa-Zamora, José García-Solano, Ginés Luengo-Gil

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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alberto Sánchez-EspinosaGroup of Molecular Pathology and Pharmacogenetics, Pathology Department, Instituto Murciano de Investigación Biosanitaria (IMIB), Hospital Universitario Santa Lucía, 30202 Cartagena, Spain.ORCID 0000-0002-2414-7045
José García-RodríguezGroup of Molecular Pathology and Pharmacogenetics, Pathology Department, Instituto Murciano de Investigación Biosanitaria (IMIB), Hospital Universitario Santa Lucía, 30202 Cartagena, Spain.
Virginia Alonso-AguirreDepartment of Radiation Oncology, Hospital Universitario Santa Lucía, 30202 Cartagena, Spain.
Jesús María Acosta-OrtegaGroup of Molecular Pathology and Pharmacogenetics, Pathology Department, Instituto Murciano de Investigación Biosanitaria (IMIB), Hospital Universitario Santa Lucía, 30202 Cartagena, Spain.
Pablo Conesa-ZamoraGroup of Molecular Pathology and Pharmacogenetics, Pathology Department, Instituto Murciano de Investigación Biosanitaria (IMIB), Hospital Universitario Santa Lucía, 30202 Cartagena, Spain.ORCID 0000-0003-0190-3044
José García-SolanoGroup of Molecular Pathology and Pharmacogenetics, Pathology Department, Instituto Murciano de Investigación Biosanitaria (IMIB), Hospital Universitario Santa Lucía, 30202 Cartagena, Spain.
Ginés Luengo-GilGroup of Molecular Pathology and Pharmacogenetics, Pathology Department, Instituto Murciano de Investigación Biosanitaria (IMIB), Hospital Universitario Santa Lucía, 30202 Cartagena, Spain.ORCID 0000-0001-9940-0415

Funding

Instituto de Salud Carlos III ICI20/00044
6 · The paper itself

Abstract

BACKGROUND/

objectivesBreast cancer is the most prevalent cancer in adult women. Currently, new therapies and protein determinations with prognostic value are under development. Fascin (encoded by the

methodsWe simultaneously assessed fascin expression and TOP2A/CEP17 DNA copy number ratios in various histological and molecular subtypes. Additionally, these markers were analyzed along with previously established diagnostic markers and other relevant clinical data.

resultsOur series included 265 patients, four of whom were male, and all of which were diagnosed with breast carcinoma. Of the 265 patients initially included, sufficient material for analysis was available for 175 cases, as some samples were excluded because of insufficient tissue quantity, poor preservation, or lack of hybridization in certain assays. Immunohistochemical (IHC) expression of fascin, both in its aggregated form and by category, showed no association with the TOP2A gene alteration ratio. Fascin expression was significantly associated with histological subtype (

conclusionsNo statistical relationship was evident between fascin expression (IHC) and the TOP2A copy ratio. The results of this study suggested that the mechanisms of increased cell proliferation associated with alterations in fascin and TOP2A are independent.

Indexed as

Biomarkers, TumorBreast NeoplasmsCarrier ProteinsDNA Topoisomerases, Type IIMicrofilament ProteinsPoly-ADP-Ribose Binding ProteinsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisBiomarkers, TumorCarrier ProteinsDNA Topoisomerases, Type IIfascinFSCN1 protein, humanMicrofilament ProteinsPoly-ADP-Ribose Binding ProteinsTOP2A protein, humanbreast cancerDNA topoisomerase 2-alphafascinimmunohistochemistrymolecular subtypes

Identifiers

PMID40243780
PMCPMC11988776

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