Evidence map›Paper›PMID 40243707›Full record

ArticleInternational journal of molecular sciences2025

The Diagnostic and Predictive Potential of miR-328 in Atrial Fibrillation: Insights from a Spontaneously Hypertensive Rat Model.

Alkora Ioana Balan, Vasile Bogdan Halaţiu, Emilian Comșulea, Cosmin Constantin Mutu, Dan Alexandru Cozac, Ioana Aspru, Delia Păcurar, Claudia Bănescu, Marcel Perian, Alina Scridon

Erratum issuedAbstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Multicellular senescence programs in the aged heart.Journal of molecular and cellular cardiology plus · 2026
    Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Alkora Ioana BalanPhysiology Department, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540139 Târgu Mureș, Romania.ORCID 0000-0001-5580-2252
Vasile Bogdan HalaţiuPhysiology Department, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540139 Târgu Mureș, Romania.ORCID 0000-0001-6793-9248
Emilian ComșuleaPhysiology Department, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540139 Târgu Mureș, Romania.ORCID 0009-0004-4234-7018
Cosmin Constantin MutuPhysiology Department, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540139 Târgu Mureș, Romania.ORCID 0009-0006-6696-6862
Dan Alexandru CozacPhysiology Department, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540139 Târgu Mureș, Romania.ORCID 0000-0002-9390-7263
Ioana AspruPhysiology Department, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540139 Târgu Mureș, Romania.
Delia PăcurarPhysiology Department, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540139 Târgu Mureș, Romania.
Claudia BănescuCenter for Advanced Medical and Pharmaceutical Research, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540139 Târgu Mureș, Romania.ORCID 0000-0002-3235-524X
Marcel PerianPhysiology Department, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540139 Târgu Mureș, Romania.
Alina ScridonPhysiology Department, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540139 Târgu Mureș, Romania.ORCID 0000-0002-9763-4266

Funding

Ministry of Research, Innovation and Digitalization PN-IV-P8-8.3-PM-RO-FR-2024-0183 contract no. 8674/2/10.09.2024
6 · The paper itself

Abstract

Using an atrial fibrillation (AF) model in spontaneously hypertensive rats (SHRs), we aimed to identify circulating miRNAs for AF diagnosis and prediction and to confirm the cardiac origin of these miRNAs. A total of 31 SHRs and 39 Wistar Kyoto (WKY) normotensive controls were randomized into six groups: young, adult, and aging SHR and WKY. Spontaneous AF burden and atrial and circulating levels of 11 miRNAs were quantified. Spontaneous AF was absent in all WKY rats. In the SHRs, AF episodes were observed in two adult animals and in all aging animals (13.6 ± 2.3 episodes/24 h). The atrial levels of five miRNAs were significantly higher in adult and aging SHRs compared to their WKY controls (all

Indexed as

Atrial FibrillationMicroRNAsAgingAnimalsBiomarkersDisease Models, AnimalHeart AtriaHypertensionMaleRatsRats, Inbred SHRRats, Inbred WKYBiomarkersMicroRNAsanimal modelatrial fibrillationdiagnostic biomarkersmicroRNAspredictive biomarkers

Identifiers

PMID40243707
PMCPMC11989045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.