Evidence map›Paper›PMID 40243683›Full record

ArticleInternational journal of molecular sciences2025

Sex-Specific Anti-Inflammatory Effects of a Ketogenic Diet in a Mouse Model of Allergic Airway Inflammation.

Carolyn D Ekpruke, Omar Borges-Sosa, Christiane A Hassel, Dustin Rousselle, Lyidia Dinwiddie, Maksat Babayev, Ahmed Bakare, Patricia Silveyra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Sex chromosomes and gonadal sex interactions in airway and immune responses to allergen challenge.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carolyn D EkprukeDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0002-9045-4457
Omar Borges-SosaDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, IN 47405, USA.
Christiane A HasselFlow Cytometry Core Facility, Indiana University, Bloomington, IN 47405, USA.
Dustin RousselleDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0003-3377-9324
Lyidia DinwiddieDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, IN 47405, USA.
Maksat BabayevDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0002-2110-4218
Ahmed BakareSchool of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-3936-1228
Patricia SilveyraDepartment of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0001-7083-8915

Funding

Indiana Clinical and Translational Sciences InstituteUM1TR004402 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI Sharon M Moe, Sarah Elizabeth Wiehe · 2023 to 2026
$21.6M
Common Themes in Reproductive DiversityT32HD049336 · NICHD · TRUSTEES OF INDIANA UNIVERSITY · PI DALE R SENGELAUB · 2005 to 2026
$4.4M
Sex differences in GPER-mediated mechanisms in allergic asthmaR01HL159764 · NHLBI · TRUSTEES OF INDIANA UNIVERSITY · PI SILVEYRA, PATRICIA · 2021 to 2024
$3.1M
National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences UM1TR004402NCATS NIH HHS UM1 TR004402NHLBI NIH HHS R01 HL159764NICHD NIH HHS T32 HD049336NIH/NHLBI R01HL159764
6 · The paper itself

Abstract

Asthma, a chronic inflammatory airway disease, leads to airflow obstruction and exhibits sex differences in prevalence and severity. Immunomodulatory diets, such as the ketogenic diet (high fat, low carbohydrate, moderate protein), may offer complementary benefits in managing airway inflammation. While anti-inflammatory effects of ketogenic diets are documented in cardiovascular diseases, their impact on asthma, especially regarding sex-specific differences, remains unexplored. Few studies on diet and asthma have considered sex as a biological factor. To test the hypothesis that a ketogenic diet affects airway inflammation in a sex-specific manner, we used a mouse allergic airway inflammation model. Male and female C57BL/6J mice (3-4 weeks old,

Indexed as

AsthmaDiet, KetogenicInflammationAllergensAnimalsDisease Models, AnimalFemaleLungMaleMiceMice, Inbred C57BLSex FactorsAllergensallergic airway inflammationallergic asthmaimmune cellsketogenic dietsex differences

Identifiers

PMID40243683
PMCPMC11989016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.