Evidence map›Paper›PMID 40243676›Full record

ArticleInternational journal of molecular sciences2025

Sublethal Concentrations of 2C-I and 25I-NBOMe Designer Drugs Impact

Eva Gil-Martins, Daniel José Barbosa, Fernando Cagide, Fernando Remião, Fernanda Borges, Renata Silva

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eva Gil-MartinsAssociate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-8142-562X
Daniel José BarbosaAssociate Laboratory i4HB-Institute for Health and Bioeconomy, University Institute of Health Sciences-CESPU, 4585-116 Gandra, Portugal.ORCID 0000-0002-1726-6011
Fernando CagideCIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.ORCID 0000-0001-9410-6874
Fernando RemiãoAssociate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0003-1382-5119
Fernanda BorgesCIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.ORCID 0000-0003-1050-2402
Renata SilvaAssociate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0001-9962-7548

Funding

Cooperativa de Ensino Superior Politécnico e Universitário Mddemy-GI2-CESPU-2022Fundação para a Ciência e Tecnologia DL57/2016/CP1346/CT0025Fundação para a Ciência e Tecnologia DL57/2016/CP1355/CT0007Fundação para a Ciência e Tecnologia LA/P/0056/2020Fundação para a Ciência e Tecnologia LA/P/0140/2020Fundação para a Ciência e Tecnologia PT-OPENSCREEN-NORTE-01-0145-FEDER-085468Fundação para a Ciência e Tecnologia SFRH/BD/146527/2019Fundação para a Ciência e Tecnologia SFRH/BPD/72923/2010Fundação para a Ciência e Tecnologia UIDB/00081/2020Fundação para a Ciência e Tecnologia UIDB/04378/2020Fundação para a Ciência e Tecnologia UIDP/04378/2020
6 · The paper itself

Abstract

Designer drugs like 2C-I and 25I-NBOMe have emerged as potent psychoactive substances, with several reports linking their consumption to severe poisoning and fatalities. However, there is limited information on their toxicity, particularly in in vivo models. In this manuscript, we evaluate the survival, developmental, and reproductive impact of these designer drugs on the model organism

Indexed as

Caenorhabditis elegansDesigner DrugsSexual Behavior, AnimalAnimalsReproductionDesigner Drugs25I-NBOMe2C-ICaenorhabditis elegansdesigner drugstoxicity

Identifiers

PMID40243676
PMCPMC11988394

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.