Evidence map›Paper›PMID 40243597›Full record

ArticleInternational journal of molecular sciences2025

Circulating Bilirubin Levels, but Not Their Genetic Determinants, Are Inversely Associated with Steatotic Liver Disease in Adolescents.

José Patricio Miranda, Juan Cristóbal Gana, Gigliola Alberti, Karen Galindo, Ana Pereira, José Luis Santos

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

José Patricio MirandaDepartment of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0002-8270-1112
Juan Cristóbal GanaDepartment of Pediatric Gastroenterology and Nutrition, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0002-0400-2164
Gigliola AlbertiDepartment of Pediatric Gastroenterology and Nutrition, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0002-8540-1326
Karen GalindoMSc Program in Nutrition, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
Ana PereiraInstituto de Nutrición y Tecnología de los Alimentos INTA, Universidad de Chile, Macul 7830490, Chile.
José Luis SantosDepartment of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0003-2895-0369

Funding

Agencia Nacional de Investigación y Desarrollo de Chile ANID FONDECYT 11190856Agencia Nacional de Investigación y Desarrollo de Chile ANID FONDECYT 1150416Agencia Nacional de Investigación y Desarrollo de Chile ANID FONDECYT 1161456Agencia Nacional de Investigación y Desarrollo de Chile ANID FONDECYT 1200839
6 · The paper itself

Abstract

Epidemiologic studies suggest that elevated plasma unconjugated bilirubin confer protection against steatotic liver disease (SLD) in adults. However, evidence supporting this protective role in adolescents remains limited. We aimed to assess the association between serum bilirubin levels and their genetic determinants in protecting against SLD in Chilean adolescents. We conducted a cross-sectional study with 704 adolescents aged 15.4 ± 1 years (52% girls) of the Chilean Growth and Obesity Cohort Study. Ultrasonography echogenicity was used to diagnose SLD. We measured Z-scores of body mass index (z-BMI), total bilirubin (TB), and the genetic determinants of bilirubin (including rs887829 genotypes of

Indexed as

BilirubinFatty LiverAdolescentBody Mass IndexChileCross-Sectional StudiesFemaleGenetic Predisposition to DiseaseGenotypeGlucuronosyltransferaseHumansMalePolymorphism, Single NucleotideUGT1A1 EnzymeBilirubinGlucuronosyltransferaseUGT1A1 EnzymebilirubinNative American ancestrypolygenic scoressteatotic liver diseaseUGT1A1

Identifiers

PMID40243597
PMCPMC11988633

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.