Evidence map›Paper›PMID 40243588›Full record

ArticleInternational journal of molecular sciences2025

PRMT7-Mediated PTEN Activation Enhances Bone Regeneration in Female Mice.

Yingfei Zhang, Jia Qing, Yang Li, Xin Gao, Dazhuang Lu, Yiyang Wang, Lanxin Gu, Hui Zhang, Zechuan Li, Xu Wang and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Advances in oral and craniofacial bone regeneration modulated by stem cells and biomaterials].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Review
  2. Special Issue "Cells and Molecules in Bone Remodeling and Repair".International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yingfei ZhangDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.
Jia QingDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.ORCID 0000-0002-2851-6848
Yang LiDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.
Xin GaoDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.
Dazhuang LuDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.ORCID 0000-0001-5681-5282
Yiyang WangDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.
Lanxin GuDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.ORCID 0000-0003-1094-2205
Hui ZhangDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.
Zechuan LiDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.
Xu WangDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.
Yongsheng ZhouDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.ORCID 0000-0002-4332-0878
Ping ZhangDepartment of Prosthodontics, Peking University Hospital of Stomatology, Beijing 100081, China.ORCID 0000-0001-8651-2100

Funding

Beijing Natural Science foundation 7242174 & L222030National Natural Science Foundation of China 81930026 & 82270954
6 · The paper itself

Abstract

Epigenetic regulation provides new insights into the mechanisms of osteogenic differentiation and identifies potential targets for treating bone-related diseases. However, the specific regulatory networks and mechanisms involved still need further investigation. In this study, we identify PRMT7 as a novel epigenetic regulator of mesenchymal stem cells (MSCs) osteogenic commitment. Conditional knockout of

Indexed as

Bone RegenerationProtein-Arginine N-MethyltransferasesPTEN PhosphohydrolaseAnimalsCell DifferentiationEpigenesis, GeneticFemaleMaleMesenchymal Stem CellsMiceMice, KnockoutOsteogenesisPRMT7 protein, mouseProtein-Arginine N-MethyltransferasesPTEN PhosphohydrolasePten protein, mousebone regenerationepigeneticsgender dimorphismH3R2me1PTEN

Identifiers

PMID40243588
PMCPMC11988880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.