Evidence map›Paper›PMID 40243535›Full record

ArticleInternational journal of molecular sciences2025

Carnitine Deficiency Caused by Salcaprozic Acid Sodium Contained in Oral Semaglutide in a Patient with Multiple Acyl-CoA Dehydrogenase Deficiency.

Yasuko Mikami-Saito, Masamitsu Maekawa, Masahiro Watanabe, Shinichiro Hosaka, Kei Takahashi, Eriko Totsune, Natsuko Arai-Ichinoi, Atsuo Kikuchi, Shigeo Kure, Hideki Katagiri and 1 more

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yasuko Mikami-SaitoDepartment of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Masamitsu MaekawaDepartment of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.ORCID 0000-0001-6723-0298
Masahiro WatanabeGraduate School of Pharmaceutical Sciences, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Shinichiro HosakaDepartment of Diabetes, Metabolism and Endocrinology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Kei TakahashiDepartment of Diabetes, Metabolism and Endocrinology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.ORCID 0000-0001-9167-2336
Eriko TotsuneDepartment of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Natsuko Arai-IchinoiDepartment of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Atsuo KikuchiDepartment of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.ORCID 0000-0003-1002-8739
Shigeo KureDepartment of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Hideki KatagiriDepartment of Diabetes, Metabolism and Endocrinology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Yoichi WadaDepartment of Pediatrics, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carnitine plays an essential role in maintaining energy homeostasis and metabolic flexibility. Various medications, such as pivalate-conjugated antibiotics, valproic acid, and anticancer agents, can induce carnitine deficiency, inhibit the utilization of fatty acid, and contribute to the development of hypoglycemia. No studies have linked oral semaglutide to carnitine deficiency. Herein, we report the case of a 34-year-old male patient with multiple acyl-CoA dehydrogenase deficiency who developed carnitine deficiency attributable to salcaprozic acid sodium (SNAC) in oral semaglutide. The patient was diagnosed with type 2 diabetes mellitus at 32 years of age and was treated with semaglutide injections. Hypoglycemic symptoms appeared after switching to oral semaglutide, and the mean levels of blood-free carnitine significantly decreased. Liquid chromatography-tandem mass spectrometry analysis revealed a peak corresponding to the SNAC-carnitine complex (

Indexed as

CarnitineGlucagon-Like PeptidesMultiple Acyl Coenzyme A Dehydrogenase DeficiencyMuscular DiseasesAdministration, OralAdultDiabetes Mellitus, Type 2Glucagon-Like Peptide 1HumansHypoglycemiaMaleSemaglutideTandem Mass SpectrometryCarnitineGlucagon-Like Peptide 1Glucagon-Like PeptidesSemaglutidecarnitine deficiencymultiple acyl-CoA dehydrogenase deficiencyoral semaglutidesalcaprozic acid sodiumtype 2 diabetes

Identifiers

PMID40243535
PMCPMC11989126

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.