Evidence map›Paper›PMID 40243530›Full record

ArticleInternational journal of molecular sciences2025

The Arg108Cys Variant of Methylmalonyl-CoA Mutase: Clinical Implications for the Mexican Population Based on Molecular Dynamics and Docking.

Marcela Vela-Amieva, Timoteo Delgado-Maldonado, Enrique Ortega-Valdez, Gildardo Rivera, Gabriel López-Velázquez, Cynthia Fernández-Lainez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marcela Vela-AmievaLaboratorio de Errores Innatos del Metabolismo y Tamiz, Instituto Nacional de Pediatría, Ciudad de México 04530, Mexico.ORCID 0000-0001-8230-4611
Timoteo Delgado-MaldonadoLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0001-8915-7351
Enrique Ortega-ValdezLaboratorio de Errores Innatos del Metabolismo y Tamiz, Instituto Nacional de Pediatría, Ciudad de México 04530, Mexico.ORCID 0009-0001-0314-4937
Gildardo RiveraLaboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.ORCID 0000-0001-9842-4167
Gabriel López-VelázquezLaboratorio de Biomoléculas y Salud Infantil, Instituto Nacional de Pediatría, Ciudad de México 04530, Mexico.ORCID 0000-0003-0470-1069
Cynthia Fernández-LainezLaboratorio de Errores Innatos del Metabolismo y Tamiz, Instituto Nacional de Pediatría, Ciudad de México 04530, Mexico.ORCID 0000-0001-7468-3420

Funding

Instituto Nacional de Pediatria 2024/032
6 · The paper itself

Abstract

Methylmalonic acidemia (MMA) is a genetic condition associated with intellectual disability and a high mortality rate. It is caused by pathogenic variants in the

Indexed as

Amino Acid Metabolism, Inborn ErrorsMethylmalonyl-CoA MutaseAdolescentCatalytic DomainChildChild, PreschoolFemaleHumansInfantMaleMexicoMolecular Docking SimulationMolecular Dynamics SimulationMethylmalonyl-CoA Mutasegenetic diseasesinborn errors of metabolismmethylmalonic acidemiapropionate defectsrare diseases

Identifiers

PMID40243530
PMCPMC11988910

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.