Evidence map›Paper›PMID 40243527›Full record

ArticleInternational journal of molecular sciences2025

Bypassing Evolution of Bacterial Resistance to Phages: The Example of Hyper-Aggressive Phage 0524phi7-1.

Maria Rojero, Meagan Weaver-Rosen, Philip Serwer

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria RojeroDepartment of Microbiology, Immunology and Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
Meagan Weaver-RosenDepartment of Biochemistry and Structural Biology, UT Health, San Antonio, TX 78229, USA.
Philip SerwerDepartment of Biochemistry and Structural Biology, UT Health, San Antonio, TX 78229, USA.ORCID 0000-0002-8990-3251

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Illumina NovaSeq 6000 Sequencing SystemS10OD030311 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2021 to 2021
$600k
Morrison Trust 2023National Science Foundation 2409676NCI NIH HHS P30 CA054174NIH HHS S10 OD030311San Antonio Medical Foundation 2024
6 · The paper itself

Abstract

The ideal bacteriophages (phages) for the treatment of bacterial disease (phage therapy) would bypass bacterial evolution to phage resistance. However, this feature (called a hyper-aggression feature) has never been observed to our knowledge. Here, we microbiologically characterize, fractionate, genomically classify, and perform electron microscopy of the newly isolated

Indexed as

Bacillus PhagesBacillus thuringiensisBacteriophagesGenome, ViralPhage Therapybacteriophage, aggregation ofbacteriophage, hibernation and swimming ofbacteriophage, plaque morphology ofbacteriophage, screening ofelectron microscopyultracentrifugation

Identifiers

PMID40243527
PMCPMC11988461

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.