Evidence map›Paper›PMID 40243506›Full record

ArticleInternational journal of molecular sciences2025

High Tumor Mutation Burden (TMB) and a Novel Somatic Mutation in the TREX1 Gene in a Patient with Aggressive and Refractory High-Grade B-Cell Lymphoma: A Case Report.

Mariia Gusakova, Fedor Sharko, Eugenia Boulygina, Natalia Slobodova, Maria Gladysheva-Azgari, Darima Badmazhapova, Artem Bullikh, Marina Khestanova, Nelli Gabeeva, Tatiana Obukhova and 2 more

Abstract readCase Reports
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mariia GusakovaNational Research Center "Kurchatov Institute", 123182 Moscow, Russia.ORCID 0000-0002-0036-9241
Fedor SharkoNational Research Center "Kurchatov Institute", 123182 Moscow, Russia.ORCID 0000-0002-1189-5597
Eugenia BoulyginaNational Research Center "Kurchatov Institute", 123182 Moscow, Russia.ORCID 0000-0003-3795-0571
Natalia SlobodovaV.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Akademika Oparina Street, 4, 117997 Moscow, Russia.
Maria Gladysheva-AzgariNational Research Center "Kurchatov Institute", 123182 Moscow, Russia.ORCID 0000-0001-5467-2986
Darima BadmazhapovaNational Medical Research Center for Hematology, 125167 Moscow, Russia.
Artem BullikhPathology Department, JSC "Medsi", 143442 Moscow, Russia.
Marina KhestanovaPathology Department, JSC "Medsi", 143442 Moscow, Russia.
Nelli GabeevaNational Medical Research Center for Hematology, 125167 Moscow, Russia.
Tatiana ObukhovaNational Medical Research Center for Hematology, 125167 Moscow, Russia.ORCID 0000-0003-1613-652X
Eugene ZvonkovNational Medical Research Center for Hematology, 125167 Moscow, Russia.
Svetlana TsygankovaNational Research Center "Kurchatov Institute", 123182 Moscow, Russia.

Funding

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation 124040300006-2
6 · The paper itself

Abstract

High-grade B-cell lymphoma (HGBL), not otherwise specified (NOS), is a rare entity within the spectrum of B-cell lymphomas. HGBL, NOS remains a diagnosis of exclusion with limited data available on the optimal clinical approach. We report a case of a 67-year-old man with HGBL, NOS with a germinal center B-cell (GCB) immunophenotype. The disease was characterized by an aggressive clinical course, refractory to multiple lines of cytotoxic chemotherapy, immunotargeted treatment, therapy with a PD-1 inhibitor, and haploidentical hematopoietic stem cell transplantation (haplo-

Indexed as

ExodeoxyribonucleasesLymphoma, B-CellMutationPhosphoproteinsAgedFatal OutcomeHumansMaleExodeoxyribonucleasesPhosphoproteinsthree prime repair exonuclease 1BCL2/IGH rearrangementGCBHGBLNOSTMB-HighTREX1whole-exome sequencing

Identifiers

PMID40243506
PMCPMC11988617

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.