Evidence map›Paper›PMID 40243495›Full record

ArticleInternational journal of molecular sciences2025

Modulation of Structural and Physical-Chemical Properties of Fish Gelatin Hydrogel by Natural Polysaccharides.

Aidar T Gubaidullin, Aliya I Galeeva, Yuriy G Galyametdinov, Georgiy G Ageev, Alexey A Piryazev, Dimitri A Ivanov, Elena A Ermakova, Alena A Nikiforova, Svetlana R Derkach, Olga S Zueva and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aidar T GubaidullinKazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, Lobachevsky St., 2/31, 420111 Kazan, Russia.ORCID 0000-0002-8114-7025
Aliya I GaleevaPhysical and Colloid Chemistry Department, Kazan National Research Technological University, 420015 Kazan, Russia.ORCID 0000-0003-0633-9366
Yuriy G GalyametdinovPhysical and Colloid Chemistry Department, Kazan National Research Technological University, 420015 Kazan, Russia.
Georgiy G AgeevScientific Center for Genetics and Life Sciences, Sirius University of Science and Technology, Olympic Avenue, 1, 354340 Sochi, Russia.ORCID 0000-0002-6546-0097
Alexey A PiryazevScientific Center for Genetics and Life Sciences, Sirius University of Science and Technology, Olympic Avenue, 1, 354340 Sochi, Russia.ORCID 0000-0002-4782-1661
Dimitri A IvanovScientific Center for Genetics and Life Sciences, Sirius University of Science and Technology, Olympic Avenue, 1, 354340 Sochi, Russia.ORCID 0000-0002-5905-2652
Elena A ErmakovaKazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, Lobachevsky St., 2/31, 420111 Kazan, Russia.
Alena A NikiforovaKazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, Lobachevsky St., 2/31, 420111 Kazan, Russia.ORCID 0009-0001-6222-9113
Svetlana R DerkachInstitute of Natural Sciences and Technology, Murmansk Arctic University, Sportivnaya Str. 13, 183010 Murmansk, Russia.
Olga S ZuevaInstitute of Electric Power Engineering and Electronics, Kazan State Power Engineering University, Krasnoselskaya St. 51, 420066 Kazan, Russia.ORCID 0000-0001-8733-0595
Yuriy F ZuevKazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, Lobachevsky St., 2/31, 420111 Kazan, Russia.ORCID 0000-0002-6715-2530

Funding

Russian Science Foundation 23-64-10020
6 · The paper itself

Abstract

Gelatin, a water-soluble protein, shows unique gellification properties, which determine the active commercial availability of gelatin hydrogels in modern alimentary, cosmetic, and pharmaceutical applications. The traditional sources of gelatin for industrial technologies are pork and bovine skin and bones, which sometimes produce religious and some other restrictions. In recent years, there has been a significant increase in the production of gelatin from alternative sources, such as raw fish materials. Unfortunately, fish gelatin is characterized by weak gelling ability and a decrease in gelation and melting temperature, which are a consequence of the amino acid composition and structural features of fish gelatin. One of the ways to strengthen the natural gelling properties of fish gelatin is the structural modification of gelatin hydrogels by the introduction of polysaccharides of various natural origins. We have studied the association of our laboratory-made fish gelatin with three polysaccharides, namely, κ-carrageenan, alginate, and chitosan, which have distinct chemical structures and gelling capabilities. Structural features of the studied systems were analyzed by small-angle X-ray scattering (SAXS), powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). We applied computer modeling of molecular interactions between fish gelatin and polysaccharides by means of molecular docking and molecular dynamics approaches. The existence of a correlation between the structure of gelatin-polysaccharide systems and their physicochemical properties was demonstrated by wetting angles (flow angles) and dynamic light scattering (DLS) studies of hydrodynamic sizes and surface ζ-potential.

Indexed as

GelatinHydrogelsPolysaccharidesAnimalsCarrageenanFishesMolecular Docking SimulationMolecular Dynamics SimulationScattering, Small AngleX-Ray DiffractionCarrageenanGelatinHydrogelsPolysaccharidesalginatechitosanfish gelatinhydrogelsstructureκ-carrageenan

Identifiers

PMID40243495
PMCPMC11988395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.