Evidence map›Paper›PMID 40243363›Full record

ArticlemBio2025

Qilu Ye, Robert Eves, Tyler D R Vance, Thomas Hansen, Adam P Sage, Andrea Petkovic, Brianna Bradley, Carlos Escobedo, Laurie A Graham, John S Allingham and 1 more

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qilu YeDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0002-5757-9514
Robert EvesDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0003-0377-1073
Tyler D R VanceDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0002-7637-5891
Thomas HansenDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0001-7515-9540
Adam P SageDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0002-4519-6970
Andrea PetkovicDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0002-1769-4008
Brianna BradleyDepartment of Chemical Engineering, Queen's University, Kingston, Ontario, Canada.ORCID 0009-0000-2970-0826
Carlos EscobedoDepartment of Chemical Engineering, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0002-7832-166X
Laurie A GrahamDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0001-7478-1557
John S AllinghamDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0002-0918-3152
Peter L DaviesDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0002-8026-7818

Funding

Protein-Glycan Interaction Resource at the National Center for Functional Glycomics (NCFG)R24GM137763 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RICHARD D CUMMINGS · 2020 to 2026
$5.8M
Canadian Foundation for Innovation 31967CIHR FRN 148422CIHR PJT-169149FEAS Excellence in Research AwardNatural Sciences and Engineering Research Council of Canada RGPIN-2019-05924Natural Sciences and Engineering Research Council of Canada RGPIN-2022-03845NIGMS NIH HHS R24 GM137763
6 · The paper itself

Abstract

Bacteria often make initial contact with their hosts through the ligand-binding domains of large adhesin proteins. Recent analyses of repeats-in-toxin (RTX) adhesins in Gram-negative bacteria suggest that ligand-binding domains can be identified by the way they emerge from "split" domains within the adhesin. Here, using this criterion and an AlphaFold3 model of a 5047-residue RTX adhesin from

Indexed as

Adhesins, BacterialAeromonas hydrophilaBacterial AdhesionCrystallography, X-RayHumansLigandsModels, MolecularProtein BindingProtein DomainsAdhesins, BacterialLigandsadhesinsAeromonasantimicrobial agentsbinding proteinsbiofilmsprotein structure–functionreceptor–ligand interaction

Identifiers

PMID40243363
PMCPMC12077191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.