Evidence map›Paper›PMID 40243333›Full record

ArticlemBio2025

A mutualistic model bacterium is lethal to non-symbiotic hosts via the type VI secretion system.

Keegan E Gaddy, Alecia N Septer, Karen Mruk, Morgan E Milton

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Keegan E GaddyDepartment of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.
Alecia N SepterDepartment of Earth, Marine and Environmental Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-9309-2930
Karen MrukDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.ORCID 0000-0003-4560-4951
Morgan E MiltonDepartment of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.ORCID 0000-0003-0458-7059

Funding

Genetic determinants of interbacterial competition during host colonizationR35GM137886 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Alecia Septer · 2020 to 2026
$2.6M
RNA-based tools for developmental and regenerative biologyR21GM143565 · NIGMS · UNIVERSITY OF WYOMING · PI MCKEAGUE, MAUREEN HOPE, MRUK, KAREN · 2021 to 2022
$356k
Regulatory mechanism of novel host-relevant biofilm formation protein in non-Cholera Vibrio speciesK22AI170662 · NIAID · EAST CAROLINA UNIVERSITY · PI MILTON, MORGAN EILISE · 2023 to 2024
$264k
NIAID NIH HHS K22 AI170662NIGMS NIH HHS R21 GM143565NIGMS NIH HHS R35 GM137886NIH HHS K22AI170662NIH HHS R21GM143565NIH HHS R35GM137886
6 · The paper itself

Abstract

What makes a bacterium pathogenic? Since the early days of germ theory, researchers have categorized bacteria as pathogens or non-pathogens, those that cause harm and those that do not, but this binary view is not always accurate.

Indexed as

Aliivibrio fischeriSymbiosisType VI Secretion SystemsZebrafishAnimalsArtemiaDecapodiformesType VI Secretion Systemspathogenicitytype IV secretion systemVibrio fischerizebrafish

Identifiers

PMID40243333
PMCPMC12077117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.