Evidence map›Paper›PMID 40243330›Full record

ArticlemBio2025

Fructose activates a stress response shared by methylglyoxal and hydrogen peroxide in

Alejandro R Walker, Danniel N Pham, Payam Noeparvar, Alexandra M Peterson, Marissa K Lipp, José A Lemos, Lin Zeng

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. AJournal of bacteriology · 2026
    Review
  3. Article
  4. Article
  5. SppR inFrontiers in cellular and infection microbiology · 2026
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Alejandro R WalkerDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.ORCID 0000-0002-5839-6584
Danniel N PhamDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Payam NoeparvarDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Alexandra M PetersonDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Marissa K LippDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.
José A LemosDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.ORCID 0000-0003-0791-5863
Lin ZengDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.ORCID 0000-0002-9269-2707

Funding

GENE REGULATION AND PHYSIOLOGY OF STREPTOCOCCUS MUTANSR01DE012236 · NIDCR · UNIVERSITY OF ROCHESTER · PI Lin Zeng · 1997 to 2026
$8.5M
Role of the Spx Regulator in Streptococcus mutansR01DE019783 · NIDCR · UNIVERSITY OF ROCHESTER · PI LEMOS, JOSE A · 2010 to 2020
$3.7M
Mechanisms of Metal Ion Homeostasis of Oral StreptococciR01DE032555 · NIDCR · UNIVERSITY OF FLORIDA · PI Jose A Lemos · 2023 to 2026
$1.8M
NIDCR NIH HHS DE032555, DE019783NIDCR NIH HHS DE12236NIDCR NIH HHS R01 DE012236NIDCR NIH HHS R01 DE019783NIDCR NIH HHS R01 DE032555
6 · The paper itself

Abstract

Fructose catabolism by

Indexed as

FructoseHydrogen PeroxidePyruvaldehydeStreptococcus mutansStress, PhysiologicalGene Expression ProfilingGene Expression Regulation, BacterialGlucoseOxidative StressZincFructoseGlucoseHydrogen PeroxidePyruvaldehydeZincF-1-Pfructosegene regulationhydrogen peroxidemetal homeostasismethylglyoxalstress response

Identifiers

PMID40243330
PMCPMC12077213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.