Evidence map›Paper›PMID 40243317›Full record

ArticleApplied and environmental microbiology2025

Modular pathway engineering for enhanced production of

Daisuke Nonaka, Mayumi Kishida, Yuuki Hirata, Ayana Mori, Akihiko Kondo, Yutaro Mori, Shuhei Noda, Tsutomu Tanaka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daisuke NonakaDepartment of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe, Hyogo, Japan.
Mayumi KishidaDepartment of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe, Hyogo, Japan.
Yuuki HirataDepartment of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe, Hyogo, Japan.
Ayana MoriDepartment of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe, Hyogo, Japan.
Akihiko KondoGraduate School of Science, Technology and Innovation, Kobe University, Kobe, Hyogo, Japan.
Yutaro MoriDepartment of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe, Hyogo, Japan.
Shuhei NodaGraduate School of Science, Technology and Innovation, Kobe University, Kobe, Hyogo, Japan.ORCID 0000-0001-5430-1966
Tsutomu TanakaDepartment of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe, Hyogo, Japan.ORCID 0000-0002-7397-7360

Funding

Asahi Glass FoundationJapan Science and Technology Agency JPMJPR22N9Japan Society for the Promotion of Science JP22H01880Japan Society for the Promotion of Science JP22H01885Japan Society for the Promotion of Science JP22KJ2279Japan Society for the Promotion of Science JP23H04565
6 · The paper itself

Abstract

The modularization of biosynthetic pathways is a promising approach for enhancing microbial chemical production. We have developed a co-utilization method with glucose and xylose substrates to divide metabolic pathways into distinct production and energy modules to enhance the biosynthesis of IMPORTANCE: Microbial biosynthesis of chemicals from renewable resources offers a sustainable alternative to fossil fuel-based production. However, inefficiencies due to substrate diversion into by-products and biomass hinder optimal yields. In this study, we employed a modular metabolic engineering approach, decoupling pathways for chemical production from cell growth. Using glucose and xylose as co-substrates, we achieved the enhancement of

Indexed as

4-Aminobenzoic AcidEscherichia coliGlucoseMetabolic EngineeringPhenylalanineXyloseBiosynthetic PathwaysMetabolic Networks and Pathways4-Aminobenzoic AcidGlucosePhenylalanineXylose4-amino-phenylalanineEscherichia colimodular metabolic engineeringp-aminobenzoic acidparallel metabolic pathway engineering

Identifiers

PMID40243317
PMCPMC12093962

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.