Evidence map›Paper›PMID 40243314›Full record

ArticleMicrobiology spectrum2025

Protein-mediated stabilization of amphotericin B increases its efficacy against diverse fungal pathogens.

Kenya E Fernandes, Caitlin L Johnston, Brayden C Williams, Dee A Carter, Margaret Sunde

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kenya E Fernandes *School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-2912-4360
Caitlin L Johnston *School of Medical Sciences and Sydney Nano, University of Sydney, Sydney, New South Wales, Australia.ORCID 0009-0006-1062-9680
Brayden C WilliamsSchool of Medical Sciences and Sydney Nano, University of Sydney, Sydney, New South Wales, Australia.ORCID 0009-0007-2713-8084
Dee A CarterSchool of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-4638-0059
Margaret SundeSydney Institute for Infectious Diseases, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-0150-3203

Funding

Department of Education and Training | Australian Research Council (ARC) DP200102463The University of Sydney Centre for Drug Discovery Innovation and the Sydney Infectious Diseases Institute
6 · The paper itself

Abstract

Amphotericin B (AMB), a potent and broad-spectrum antifungal agent, faces solubility and toxicity challenges in clinical use. In this study, we explored the ability of DewY and EAS

Indexed as

Amphotericin BAntifungal AgentsFungal ProteinsFungiDrug StabilityHydrophobic and Hydrophilic InteractionsMicrobial Sensitivity TestsSolubilityAmphotericin BAntifungal AgentsFungal Proteinsamphotericin Bantifungalscombination therapyhydrophobins

Identifiers

PMID40243314
PMCPMC12131825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.