Evidence map›Paper›PMID 40243214›Full record

Trial reportMovement disorders : official journal of the Movement Disorder Society2025

Transcutaneous Tibial Nerve Stimulation for Overactive Bladder Symptoms in Parkinson's Disease: Results from a Phase II Randomized Control Trial (STRIPE).

Matthew D Smith, Gabriella E Portlock, Anisha Cullen, Anahita Nodehi, Marcus J Drake, Yoav Ben-Shlomo, Emily J Henderson

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew D SmithAgeing and Movement Research Group, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-4685-375X
Gabriella E PortlockAgeing and Movement Research Group, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Anisha CullenAgeing and Movement Research Group, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Anahita NodehiAgeing and Movement Research Group, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Marcus J DrakeDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College, London, United Kingdom.
Yoav Ben-ShlomoAgeing and Movement Research Group, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Emily J HendersonAgeing and Movement Research Group, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-0016-1870

Funding

Gatsby Charitable Foundation GAT3676
6 · The paper itself

Abstract

backgroundLower urinary tract symptoms (LUTS) are common Parkinson's disease (PD), causing great impact.

objectiveThe goal was to undertake a phase II randomized control trial of transcutaneous tibial nerve stimulation (TTNS) delivered by Geko device for LUTS related to overactive bladder (OAB) in PD, an easy to use of the shelf solution.

methodsParticipants were randomized to active/sham stimulation. Primary outcome measure was the International Consultation on Incontinence Questionnaire-Overactive Bladder score (ICIQ-OAB) at 12 weeks.

resultsA total of 148 participants were allocated to active (73) and sham arms (75). No difference was seen between arms (coefficient, 0.48; 95% CI, -0.2 to 1.2; P = 0.17), although both active and sham showed improvements over baseline. Pain was the most common adverse event.

conclusionNo difference was seen between active and sham arms. Symptom improvements seen in both groups are consistent with a placebo effect, however, we cannot exclude a biological effect from the sham intervention. Although negative, this result should be taken only in context of Geko use rather TTNS in general. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

Parkinson DiseaseTibial NerveTranscutaneous Electric Nerve StimulationUrinary Bladder, OveractiveAgedFemaleHumansMaleMiddle AgedTreatment OutcomeautonomicbladderneuromodulationoveractiveParkinson's

Identifiers

PMID40243214
PMCPMC12273607

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.