Evidence map›Paper›PMID 40243204›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2025

Nicolas V Janto, Antoine R Gleizes, Siyang J Sun, Gurel Ari, Vivek Rao, Adam D Gracz

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Tet1 safeguards lineage allocation in intestinal stem cells.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

  • Update of
    2024
5 · Who and what money

Authors and funding

6 authors.

Nicolas V JantoDepartment of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia, United States.ORCID 0000-0003-3717-2220
Antoine R GleizesDepartment of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia, United States.
Siyang J SunDepartment of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia, United States.
Gurel AriDepartment of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia, United States.
Vivek RaoDepartment of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia, United States.
Adam D GraczDepartment of Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia, United States.ORCID 0000-0003-1298-568X

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
Regulation of intestinal stem cell state by ID3R35GM142503 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Adam David Gracz · 2021 to 2026
$2.5M
Determining the role of Tet1 in facultative intestinal stem cellsF31DK136254 · NIDDK · EMORY UNIVERSITY · PI JANTO, NICOLAS VAUGHAN · 2023 to 2025
$146k
EU | Integrated Cellular Imaging Core, Emory University (ICI) RRID:SCR_023534EU | Winship Cancer Institute (Winship Cancer Institute of Emory University)HHS | NIH | National Cancer Institute (NCI) P30CA138292HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) F31DK136254HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM142503HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM008490NCI NIH HHS P30 CA138292NIDDK NIH HHS F31 DK136254NIGMS NIH HHS R35 GM142503NIGMS NIH HHS T32 GM008490
6 · The paper itself

Abstract

Doxorubicin (DXR) is a widely used chemotherapy drug that can induce severe intestinal mucositis. Although the influence of gut bacteria on DXR-induced damage has been documented, the role of eukaryotic commensals remains unexplored. We discovered

Indexed as

Antibiotics, AntineoplasticApoptosisDoxorubicinIntestinal MucosaTritrichomonasAnimalsGastrointestinal MicrobiomeMaleMiceMice, Inbred C57BLAntibiotics, AntineoplasticDoxorubicinapoptosisdoxorubicinintestinal epitheliummicrobiomeTritrichomonas muris

Identifiers

PMID40243204
PMCPMC12094299

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.