Trial reportJournal of cosmetic dermatology2025
A Novel Technology to Boost Natural Production of Hyaluronic Acid in the Skin Tissue: Human Histology Study.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05987917 (Clinical and Histological Evaluation of BTL-785F Non-invasive Treatment for Facial Rejuvenation), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Histological Evaluation of BTL-785F Non-invasive Treatment for Facial Rejuvenation
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
introductionCombining monopolar radiofrequency (RF) with targeted ultrasound (TUS), this study investigated whether these modalities promote facial rejuvenation through the production of hyaluronic acid (HA) in human skin.
methodsSeven subjects (51-64 years, BMI 21.1-29.8 kg/m
resultsThere was a statistically significant (p < 0.05) average increase at 1 month in the HA-stained area of +112 358.7 μm
conclusionOverall, this study has shown that the combination treatment of RF + TUS has a more pronounced and sustained effect on facial rejuvenation compared to RF alone. The measurable increase in the production of HA with simultaneous use of RF + TUS peaked at a 3-month follow-up, suggesting the gradual advancement of the treatment effect and overall improvement in facial appearance.
trial registrationClinicalTrials.gov identifier: NCT05987917.
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