Evidence map›Paper›PMID 40243111›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Micro-Coil Neuromodulation at Single-Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures.

Kayeon Kim, Xiyuan Liu, Bingdong Chang, Guanghui Li, Gwendoline A E Anand, Su Genelioglu, Alexandra Katherine Isis Yonza, Andrew J Whalen, Rune W Berg, Shelley I Fried and 2 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. "Tone-Arm" Neuromodulation MEMS Microcoil for In Vivo Imaging.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kayeon KimDepartment of Neuroscience, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2200, Denmark.ORCID https://orcid.org/0000-0002-4565-9429
Xiyuan LiuDepartment of Neuroscience, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2200, Denmark.
Bingdong ChangDepartment of Civil and Mechanical Engineering, Technical University of Denmark, Lyngby, 2800, Denmark.
Guanghui LiDepartment of Neuroscience, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2200, Denmark.
Gwendoline A E AnandDepartment of Civil and Mechanical Engineering, Technical University of Denmark, Lyngby, 2800, Denmark.
Su GeneliogluDepartment of Civil and Mechanical Engineering, Technical University of Denmark, Lyngby, 2800, Denmark.
Alexandra Katherine Isis YonzaDepartment of Neuroscience, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2200, Denmark.
Andrew J WhalenDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, 06510, USA.
Rune W BergDepartment of Neuroscience, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2200, Denmark.
Shelley I FriedBoston VA Healthcare System, Boston, MA, 02130, USA.
Anpan HanDepartment of Civil and Mechanical Engineering, Technical University of Denmark, Lyngby, 2800, Denmark.ORCID https://orcid.org/0000-0001-6878-9886
Changsi CaiDepartment of Neuroscience, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, DK-2200, Denmark.

Funding

Investigating the Response of CNS Neurons to Electric and Magnetic StimulationR01NS110575 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI FRIED, SHELLEY · 2019 to 2023
$3.4M
Development of a Micro-coil Based Cochlear ImplantR01DC019916 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI JULIE G Arenberg, Shelley Fried · 2023 to 2026
$2.1M
BLRD VA I01 BX005959Danmarks Frie Forskningsfond 1133-00016BLundbeck Foundation R305-2018-2779Lundbeck Foundation R345-2020-1440Lundbeck Foundation R402-2022-1530National Institute of Deafness and Communication Disorders R01-DC019916NIDCD NIH HHS R01 DC019916NIMH NIH HHS R01-ME130490NINDS NIH HHS R01 NS110575NINDS NIH HHS R01-NS110575Nordea-fondenNovo Nordisk Fonden NNF0064289
6 · The paper itself

Abstract

Micromagnetic stimulation (µMS) emerges as a complementary method for neuromodulation. Despite major advances in neural interface technology, there are limited options for neural inhibition. Here, a microchip-based implantable micro-coil device is presented to achieve high spatial precision for cortical inhibition. Cortical in vivo two-photon imaging of spontaneous neural activity showed µMS reversibly suppressed single cells, and as µMS magnitude is increased, the suppressed cell population increased from 14% to 41%. At the circuit level, the average suppressed area is 0.05 mm

Indexed as

NeuronsSeizuresAnimalsElectric StimulationMaleMiceSingle-Cell AnalysisMEMs micro‐coilneural inhibitionneural interfacesingle‐cell studytwo‐photon imaging

Identifiers

PMID40243111
PMCPMC12165067

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.