ArticleJournal of magnetic resonance imaging : JMRI2025
Brain Tumor Characterization Using Multiple MR Parameters From Multi-Contrast EPI With Keyhole (GE-SE EPIK) Including Oxygen Extraction Fraction: A Comparison to O-(2-[18F]Fluoroethyl)-L-Tyrosine (FET) Positron Emission Tomography.
Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Brain Tumor Characterization Using Multiple MR Parameters From Multi-Contrast EPI With Keyhole (GE-SE EPIK) Including Oxygen Extraction Fraction: A Comparison to O-(2-[18F]Fluoroethyl)-L-Tyrosine (FET) Positron Emission Tomography.Journal of magnetic resonance imaging : JMRI · 2025Article
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11 authors.
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Abstract
backgroundTumor characterization and treatment efficacy are associated with tissue hypoxia. MR-derived oxygen extraction fraction (OEF) may offer valuable tumor insights but depends on multiple measurement parameters, often requiring multiple sequence acquisitions. Specific multi-parametric sequences offer direct access to MR parameter sets within short acquisition times. PURPOSE: To evaluate the potential of gradient-echo spin-echo echo-planar imaging with keyhole (GE-SE EPIK)-derived parameters (OEF/T STUDY TYPE: Retrospective. POPULATION: Fifty-seven brain tumor patients (female/male:31/26; age 27-73 years) with 66 histologically confirmed lesions (suspected glioblastoma (16), glioblastoma (28), astrocytoma (11), metastasis (6), oligodendroglioma (5)). FIELD STRENGTH/SEQUENCE: 10-echo GE-SE EPIK sequence at 3 T. ASSESSMENT: GE-SE EPIK data were acquired in a hybrid MR PET scanner during FET PET acquisitions. Two tumor segmentations based on FET-PET uptake and FLAIR hyperintensities were manually created. Mean GE-SE EPIK-derived parameters were calculated within tumor regions and compared to contralateral reference values. Relative tumor-to-reference parameters were compared across tumor types. STATISTICAL TESTS: One/two-sampled, two-tailed t-tests of mean relative MR-derived parameters. p-value < 0.05 was considered significant.
resultsSignificantly increased T DATA
conclusionGE-SE EPIK provides multiple MR parameters that are sensitive to expected changes in tumor regions obtained from FET and FLAIR thresholds. Susceptibility artifacts in T EVIDENCE LEVEL: 3. TECHNICAL EFFICACY: Stage 2.
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