ArticleAngewandte Chemie (International ed. in English)2025
Spatio-Temporal Processes of Diffusion-Controlled Communication in Hierarchical Multi-Compartments.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Spatially Encoded Protocell Network for Non-Cascaded Parallel Biocomputation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spatio-Temporal Processes of Diffusion-Controlled Communication in Hierarchical Multi-Compartments.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Exploring the synergy of feedback behavior and molecular communication between micro- and nanocompartments is of great implication for the development of advanced hierarchical living-like materials. Non-covalent interactions are the driving forces for dynamic and temporal events in biomimetic structures. Herein, pH-responsive hierarchical multi-compartments (HMC) are constructed via hydrophobic-hydrophobic interactions between azobenzene units and phospholipid layers through the integration of two distinct structural units: phospholipid-membranized coacervates (Coa@DMPC) and azobenzene-functionalized polymersomes (Azo-Psomes). This enables us to study spatio-temporal signal pathways for biomimetic pH homeostasis and the triggering of feedback-controlled peroxidase-like behavior of Azo-Psomes within HMC. Compared with undocking systems, the information transmission process within HMC shows a high efficiency. Besides the continuous addition of nutrients, the synchronization of two different biomimetic reactions in HMC requires the spatial loading of glucose oxidase and L-phenylalanine ammonia lyase in coacervates and of L-phenylalanine or beta-cyclodextrin/hemin complexes in Azo-Psomes. Azo-Psomes exhibit pH-responsive feedback-controlled behavior. The pH-responsive membrane of Azo-Psomes is responsible for the spatio-temporal peroxidase-like activity of lumen-integrated beta-cyclodextrin/hemin complexes in Azo-Psomes. Finally, this strategy provides a new approach for constructing more complex biomimetic systems by interconnecting at least two membrane-containing compartments to further explore the synergistic mechanisms and feedback behaviors among artificial cell communities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.