Evidence map›Paper›PMID 40242865›Full record

ArticleCirculation research2025

Reducing Granules Without Splicing Restoration Alleviates RBM20 Cardiomyopathy.

Mei Methawasin, Yanghai Zhang, Zachery R Gregorich, Yaqin He, Chunling Liu, Julia Muldoon, Zaynab Hourani, John E Smith, Henk Granzier, Wei Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Novel Truncating Variant c.1222DupC inCirculation. Genomic and precision medicine · 2026
    Article
  2. Article
  3. Review
  4. Early Onset Heart Failure due toClinical case reports · 2026
    Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mei Methawasin *Department of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson (M.M., J.M., Z.H., J.E.S., H.G.).ORCID 0000-0002-2509-1936
Yanghai Zhang *Department of Animal and Dairy Sciences, (Y.Z., Z.R.G., Y.H., C.L., W.G.), University of Wisconsin-Madison.ORCID 0009-0003-5307-6148
Zachery R GregorichDepartment of Animal and Dairy Sciences, (Y.Z., Z.R.G., Y.H., C.L., W.G.), University of Wisconsin-Madison.
Yaqin HeDepartment of Animal and Dairy Sciences, (Y.Z., Z.R.G., Y.H., C.L., W.G.), University of Wisconsin-Madison.
Chunling LiuDepartment of Animal and Dairy Sciences, (Y.Z., Z.R.G., Y.H., C.L., W.G.), University of Wisconsin-Madison.
Julia MuldoonDepartment of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson (M.M., J.M., Z.H., J.E.S., H.G.).
Zaynab HouraniDepartment of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson (M.M., J.M., Z.H., J.E.S., H.G.).
John E SmithDepartment of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson (M.M., J.M., Z.H., J.E.S., H.G.).ORCID 0000-0002-0888-1274
Henk GranzierDepartment of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson (M.M., J.M., Z.H., J.E.S., H.G.).ORCID 0000-0002-9516-407X
Wei GuoDepartment of Animal and Dairy Sciences, (Y.Z., Z.R.G., Y.H., C.L., W.G.), University of Wisconsin-Madison.ORCID 0000-0002-9158-8107

Funding

Role of the giant protein titin in cardiac health and diseaseR35HL144998 · NHLBI · UNIVERSITY OF ARIZONA · PI GRANZIER, HENK L. · 2019 to 2025
$6.3M
Posttranscriptional Regulation of RNA Binding Proteins in Heart FailureR01HL148733 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GUO, WEI · 2020 to 2023
$1.5M
Sex-specific myofilament dysfunction in postmenopausal HFpEFR01HL171047 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Mei Methawasin · 2024 to 2026
$1.3M
American Heart Association-American Stroke Association 19TPA34830072American Heart Association-American Stroke Association 23TPA1069731NHLBI NIH HHS R01 HL148733NHLBI NIH HHS R01 HL171047NHLBI NIH HHS R35 HL144998
6 · The paper itself

Abstract

backgroundRBM20 (RNA binding motif protein 20) cardiomyopathy is a severe form of dilated cardiomyopathy (DCM). Genetic variants in the nuclear localization signal of

methodsWe downregulated

resultsThe results revealed that reducing the level of

conclusionsThe findings of this study demonstrated that RNP granules serve as a critical driver for RBM20 cardiomyopathy, and reduction of RNP granules through treatment with ASOs is a possible therapeutic option for RBM20 cardiomyopathy in patients carrying

Indexed as

Cardiomyopathy, DilatedCytoplasmic GranulesMyocytes, CardiacRibonucleoproteinsRNA-Binding ProteinsAnimalsConnectinDisease Models, AnimalMaleMiceMice, Inbred C57BLOligonucleotides, AntisenseProtein KinasesConnectinOligonucleotides, AntisenseProtein KinasesRBM20 protein, mouseRibonucleoproteinsRNA-Binding Proteinstitin protein, mousealternative splicingarrhythmias, cardiaccardiomyopathy, dilatedmuscle, striatedoligonucleotides, antisense

Identifiers

PMID40242865
PMCPMC12064375

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.