Evidence map›Paper›PMID 40242836›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Late-midlife lifestyle and brain and cognitive changes in individuals on the AD versus non-AD continuum.

Julie E Oomens, Karly A Cody, Lianlian Du, Erin M Jonaitis, Rachel L Studer, Nathaniel A Chin, Sebastian Köhler, Pieter Jelle Visser, Stephanie J B Vos, Rebecca E Langhough and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Prospective study on physical activity and Alzheimer's disease-related biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julie E OomensDepartment of Psychiatry and Neuropsychology School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University Maastricht The Netherlands.ORCID https://orcid.org/0000-0002-5201-8080
Karly A CodyWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health University of Wisconsin-Madison Madison Wisconsin USA.
Lianlian DuWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health University of Wisconsin-Madison Madison Wisconsin USA.
Erin M JonaitisWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health University of Wisconsin-Madison Madison Wisconsin USA.
Rachel L StuderWisconsin Alzheimer's Institute School of Medicine and Public Health University of Wisconsin-Madison Madison Wisconsin USA.
Nathaniel A ChinWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health University of Wisconsin-Madison Madison Wisconsin USA.
Sebastian KöhlerDepartment of Psychiatry and Neuropsychology School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University Maastricht The Netherlands.
Pieter Jelle VisserDepartment of Psychiatry and Neuropsychology School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University Maastricht The Netherlands.
Stephanie J B VosDepartment of Psychiatry and Neuropsychology School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University Maastricht The Netherlands.
Rebecca E LanghoughWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health University of Wisconsin-Madison Madison Wisconsin USA.
Willemijn J JansenDepartment of Psychiatry and Neuropsychology School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University Maastricht The Netherlands.
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health University of Wisconsin-Madison Madison Wisconsin USA.

Funding

Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
The Longitudinal Course of Neural Function and Amyloid in People At Risk for ADR01AG021155 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson · 2004 to 2026
$27.0M
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)R01AG054059 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAREY E GLEASON · 2016 to 2026
$15.3M
NIA NIH HHS R01 AG021155NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG054059
6 · The paper itself

Abstract

introductionWe investigated whether a composite measure of late-midlife lifestyle was associated with (1) longitudinal brain changes and (2) cognitive changes when adjusting for these brain changes.

methodsWe used linear mixed models to examine whether the LIfestyle for BRAin Health (LIBRA) index was associated with changes in tau, white matter hyperintensity, neurodegeneration, and cognition and whether changes were similar in amyloid positive (A+; > 17 Centiloids) and negative participants.

resultsWe included 324 individuals from the Wisconsin Registry for Alzheimer's Prevention (39% apolipoprotein E [ DISCUSSION: In the age-range and disease-range studied, lifestyle did not exhibit a meaningful effect on Alzheimer's disease or vascular biomarker accumulation and was not consistently associated with cognitive trajectories. Highlights: In this age-range, the LIfestyle for BRAin Health (LIBRA) index was not associated with biomarker trajectories.The LIBRA index was not consistently associated with cognitive trajectories.Effects of lifestyle, if any, may take more time to manifest.

Indexed as

Alzheimer's diseasebiomarkerscognitionglobal brain atrophyhippocampal volumelifestyleLIfestyle for BRAin Health indextau PETwhite matter hyperintensityWisconsin Registry for Alzheimer's Prevention

Identifiers

PMID40242836
PMCPMC12000247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.