Evidence map›Paper›PMID 40242765›Full record

ArticleFrontiers in immunology2025

Distinct immune memory induced by SARS-CoV-2 in convalescent liver transplant recipients.

Mengcheng Liu, Feng Wu, Binwei Duan, Yuxuan Zhang, Wenjing Wang, Zhuangzhuang Chen, Yibo Sun, Gongming Zhang, Yifei Wang, Yueyi Sun and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mengcheng Liu *Department of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Feng Wu *Department of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Binwei Duan *Department of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Yuxuan Zhang *Department of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Wenjing WangDepartment of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Zhuangzhuang ChenDepartment of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Yibo SunDepartment of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Gongming ZhangDepartment of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Yifei WangDepartment of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Yueyi SunDepartment of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Yabo OuyangDepartment of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Guangming LiDepartment of General Surgery Center, Beijing YouAn Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The understanding of how the host immune response differs in T-cell phenotype and memory formation during SARS-CoV-2 infection in liver transplant recipients (LTRs) remains limited. LTRs who recovered from COVID-19 infection without prior vaccination represent a unique population for studying immune responses to SARS-CoV-2. Six LTRs with positive neutralizing antibodies (nAb+) and six LTRs with negative nAb (nAb-) were included at 6 months following COVID-19 infection. It was found that nAb+ LTRs had higher anti-RBD IgG titers and greater neutralizing percent inhibition compared to nAb- LTRs. Fifteen T-cell subsets were identified in COVID-19 convalescent LTRs, and it was shown that only terminal effector CD8+ - 3 decreased in the nAb+ group, while elevated IL-10 expression levels were found in the nAb- group. After stimulation with the SARS-CoV-2 XBB spike peptide pool

Indexed as

COVID-19Immunologic MemoryLiver TransplantationSARS-CoV-2AdultAgedAntibodies, NeutralizingAntibodies, ViralCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesConvalescenceFemaleHumansInterleukin-10MaleMiddle AgedAntibodies, NeutralizingAntibodies, ViralInterleukin-10Spike Glycoprotein, Coronavirusimmune memoryliver transplant recipientsneutralizing antibodiesSARS-CoV-2 convalescentT cell phenotype

Identifiers

PMID40242765
PMCPMC12000081

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.