Evidence map›Paper›PMID 40242761›Full record

ArticleFrontiers in immunology2025

Distinct Omicron longitudinal memory T cell profile and T cell receptor repertoire associated with COVID-19 hospitalisation.

Gavin Markey, Joseph McLaughlin, Darren McDaid, Seodhna M Lynch, Andrew English, H Denis Alexander, Martin Kelly, Manav Bhavsar, Victoria McGilligan, Shu-Dong Zhang and 6 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Gavin Markey *Personalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
Joseph McLaughlin *Personalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
Darren McDaidPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
Seodhna M LynchPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
Andrew EnglishPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
H Denis AlexanderPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
Martin KellyIntensive Care Unit, Western Health Social Care Trust, Londonderry, United Kingdom.
Manav BhavsarIntensive Care Unit, Western Health Social Care Trust, Londonderry, United Kingdom.
Victoria McGilliganPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
Shu-Dong ZhangPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
Elaine K MurrayPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
Taranjit Singh RaiPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
Colum WalshGenomic Medicine Research Group, School of Biomedical Science, Ulster University, Coleraine, United Kingdom.
Anthony J BjoursonPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
Priyank ShuklaPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.
David S GibsonPersonalised Medicine Centre, School of Medicine, Ulster University, Londonderry, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 has claimed more than 7 million lives worldwide and has been associated with prolonged inflammation, immune dysregulation and persistence of symptoms following severe infection. Understanding the T cell mediated immune response and factors impacting development and continuity of SARS-CoV-2 specific memory T cells is pivotal for developing better therapeutic and monitoring strategies for those most at risk from COVID-19. Here we present a comprehensive analysis of memory T cells in a convalescent cohort (n=20), three months post Omicron infection. Utilising flow cytometry to investigate CD4

Indexed as

COVID-19Immunologic MemoryMemory T CellsReceptors, Antigen, T-CellSARS-CoV-2AdultAgedCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesEpitopes, T-LymphocyteFemaleHospitalizationHumansInterleukin-2MaleMiddle AgedEpitopes, T-LymphocyteInterleukin-2Receptors, Antigen, T-Celladaptive immunityantigen presentationCOVID-19immuno-informaticsSARS-CoV-2T cell immunityT cell receptor (TCR) recognition

Identifiers

PMID40242761
PMCPMC12000046

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.