ArticleJournal of inflammation research2025
Efficacy of Cooling Blankets and Cold Fluid Infusions in Classic Heatstroke Treatment: A Controlled Study in Rats.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Heat-Related Illness and Heatstroke: A Narrative and Clinical Review for Emergency Clinicians.Cureus · 2026Review
- The neural thermostat malfunction: revisiting heatstroke through the lens of warm-sensitive neuron dysregulation.Frontiers in cellular neuroscience · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Rapid core temperature reduction is crucial for treating heatstroke. Clinical methods like cooling blankets and cold fluid infusions are common, but their specific effects are not well defined. This study evaluates these methods' cooling effects and prognosis impact in classic heatstroke rats. Methods: Sixty Sprague Dawley rats with classic heatstroke were divided into five groups: cooling blanket, cold fluid infusion, combination (combined cooling blanket and cold fluid infusion), natural cooling (control), and cold water immersion (positive control). Core temperature and mean arterial pressure were monitored. Blood samples were taken at 0.5 and 2 hours post-cooling for analysis. Half the rats underwent pathological evaluation and apoptosis analysis of heart and kidney tissues at 2 hours. The rest were observed for 24-hour survival. Results: The combination group showed the fastest cooling within 10 minutes. Cooling blanket and cold fluid infusion groups had similar cooling rates. Heart and kidney function indicators and inflammatory cytokine levels were significantly lower in the combination and cold fluid infusion groups compared to the cooling blanket group. Pathological damage was highest in the cooling blanket group. Cooling rate negative correlated with organ function indicates and inflammation markers. No rats in the cooling groups died, while seven in the natural cooling group did. Conclusion: Cooling methods differ in effectiveness and impact on inflammation and organ function. While cooling blankets demonstrate limited therapeutic efficacy and potential risks when used in isolation, rapid cold fluid infusion emerges as the preferred cooling modality by preserving cardiac structure and renal function while attenuating systemic inflammation. Early rapid cooling improves organ function and prognosis in classic heatstroke rats. Proper cooling methods are crucial for effective heatstroke management, reducing organ damage, and improving survival rates.
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Registered trials
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