ArticleCureus2025
Expression of Epithelial-Mesenchymal Transition-Related Protein Claudin-10 in Oral Lichen Planus.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
introductionOral lichen planus (OLP) is a common skin disease of indeterminate etiology that can affect the oral mucosa. Epithelial-mesenchymal transition (EMT) is a critical biological event that plays an essential role in several functions, such as development, tissue repair, and stem cell dynamics, but also in cancer progression. Claudin-10, an EMT-related protein, is encoded by the CLDN10 gene in humans. In the present work, we studied the immunohistological expression of Claudin-10 in OLP compared to normal oral mucosa.
methodsFifty-one formalin-fixed, paraffin-embedded samples diagnosed as OLP from patients who did not receive any medications for the treatment of OLP until the initial biopsy and ten formalin-fixed, paraffin-embedded samples diagnosed as comprising histologically normal oral mucosa tissue from resection margins of fibromas were immunohistochemically stained and analyzed for Claudin-10.
resultsThe expression of Claudin-10 was evaluated as significantly enhanced in OLP epithelium compared to controls (
conclusionsThe immunohistological expression of Claudin-10 has been described and analyzed in oral mucosal disease for the first time. Our findings indicate that the expression of Claudin-10 is dysregulated in OLP, possibly showing an interaction between the epithelium and the underlying tissue.
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