ReviewInternational journal of nanomedicine2025
From Citrus to Clinic: Limonene's Journey Through Preclinical Research, Clinical Trials, and Formulation Innovations.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Tissue-Specific Bioactive Metabolites and Antioxidant Activity in Minicitrus (Antioxidants (Basel, Switzerland) · 2026Article
- Article
- Plant-Derived Terpenes as Emerging Therapeutics Against Schistosomiasis.International journal of molecular sciences · 2026Review
- Research progress on self-assembled supramolecular bioactive materials from herbal natural products and their applications in anti-infection field.Materials today. Bio · 2026Review
- Chemical Characterization and Evaluation of Antimicrobial, Antioxidant, and Synergistic Activities ofPharmaceutics · 2026Article
- Subacute Oral Toxicity Evaluation of Red Pine Oil in Sprague-Dawley Rats: Safety Profiling for Potential Therapeutic Use.Journal of toxicology · 2026Article
- Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery.Frontiers in oncology · 2026Review
- Dose-Sparing Efficacy of d-Limonene with Low-Dose Allopurinol in a Dual Model of Hyperuricemia and Gouty Arthritis in Rats.Nutrients · 2025Article
- Targeting chemical carcinogenesis: α-pinene and D-limonene as chemopreventive agents against NNK/TCDD- and urethane-induced lung tumorigenesis.Journal of food and drug analysis · 2025Article
- D-limonene attenuates D-galactose-induced skin aging mouse model.Journal of molecular histology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Limonene is a naturally occurring monoterpene found in oranges, lemons, grapefruit, fennel, and caraway, and is a part of essential oils of different plants. It has caught the eye of the research community owing to its innumerable health benefits. It exhibits significant antioxidant, anti-inflammatory, wound-healing, antidiabetic, anticancer, and immunomodulatory activities. These activities of limonene render it an indispensable compound in both traditional and modern medicine. This article presents a thorough compilation of the various therapeutic activities of limonene and the mechanisms underlying them. Furthermore, it delves into an in-depth discussion of the role of nanoformulations and novel drug delivery systems in ensuring the targeted delivery of limonene. To substantiate the safety and efficacy of limonene, a large number of preclinical and clinical studies have been conducted by researchers have also been discussed in detail in this review. Limonene is an unparalleled terpenoid with numerous therapeutic benefits. Incorporating it into sophisticated drug delivery systems and medical devices, together with personalised medicine strategies, signifies notable progress in its therapeutic use. Technologies, such as 3D printing, nanoformulations, and microneedles, can improve the ability of limonene to be absorbed by the body and targeted to specific areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.