ArticleAlzheimer's & dementia (New York, N. Y.)
Physical activity modifies associations between cerebrospinal fluid tau measures and executive function.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Associations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults.npj aging · 2026Article
- Concurrent associations between visit-to-visit changes in actigraphy-based physical activity and cognitive aging in older adults.Neurobiology of aging · 2026Article
- Physical activity across the life course and neural biomarkers.Journal of Alzheimer's disease : JAD · 2026Article
- Rising energetic cost of walking predicts cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Amyloid-beta relates to default and attention network connectivity during working memory retrieval.Brain communications · 2026Article
- Longitudinal associations of rest-activity rhythms with executive function, plasma biomarkers, and clinical outcomes in older adults.Frontiers in aging neuroscience · 2026Article
- Physical activity modifies associations between cerebrospinal fluid tau measures and executive function.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundAlzheimer's disease (AD) is characterized by the abnormal accumulation of amyloid-beta (Aβ) and tau that can be quantified in vivo through cerebrospinal fluid (CSF) sampling. Physical activity has emerged as a possible modifier of AD risk; however, its impact on CSF biomarkers and cognitive function is not yet fully understood. We examined whether higher levels of physical activity modifies associations between AD CSF biomarkers and cognitive function.
methodsOne hundred and seventeen adults free of dementia from the BIOCARD study (mean age 72.2 ± 8.0 years, 70% women) wore a wrist accelerometer for 1 week, underwent lumbar puncture to collect CSF, and completed a comprehensive neuropsychological exam. Multivariable linear regression analyses were used to examine whether physical activity (total activity counts over the 10 most active hours of the day) moderates the association between AD CSF biomarkers [Aβ42/40, phosphorylated tau (p-tau181), and total tau] and cognitive composite scores (episodic memory, executive function).
resultsThere were significant interactions between physical activity and p-tau181 (
conclusionA physically active lifestyle may provide protection against AD-related cognitive decline by reducing the impact of tau pathology. Highlights: Older age was associated with lower levels of physical activity, worse CSF biomarker profiles, and poorer cognition.Physical activity moderates the impact of tau pathology on executive function but shows no significant effect on amyloid-beta pathology.Physical activity may enhance cognitive reserve, thereby attenuating the influence of accumulating AD pathology on cognition.
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