Evidence map›Paper›PMID 40242563›Full record

ArticleEClinicalMedicine2025

AutoCOPD-A novel and practical machine learning model for COPD detection using whole-lung inspiratory quantitative CT measurements: a retrospective, multicenter study.

Fanjie Lin, Zili Zhang, Jian Wang, Cuixia Liang, Jiaxuan Xu, Xiansheng Zeng, Qingpeng Zeng, Huai Chen, Jiayu Zhuang, Yu Ma and 16 more

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Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Nasal Microbiota Associated with the Lung Radiomic Features in Asthma.International journal of general medicine · 2026
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

26 authors.

Fanjie LinState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Zili ZhangState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Jian WangState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Cuixia LiangNeusoft Medical Systems Co., Ltd. Shenyang, Liaoning, PR China.
Jiaxuan XuState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Xiansheng ZengDepartment of Respiratory and Critical Care Medicine, Xiangyang Key Laboratory of Respiratory Health Research, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, PR China.
Qingpeng ZengState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Huai ChenDepartment of Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Jiayu ZhuangState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Yu MaDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.
Qiao MaDepartment of Respiratory and Critical Care Medicine, Xiangyang Key Laboratory of Respiratory Health Research, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, PR China.
Raymond ShiState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Jingyi XuState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Yuanyuan LiState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Liang YuanState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Xinguang WeiState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Lulu WuState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Renjun HuangState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Tianchi XiaoState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Wenhua LiangDepartment of Thoracic Surgery and Oncology, State Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Jinping ZhengState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Jianxing HeDepartment of Thoracic Surgery and Oncology, State Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Yun LiuDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.
Zhenyu LiangState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Nanshan ZhongState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Wenju LuState Key Laboratory of Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The rate of diagnosis for chronic obstructive pulmonary disease (COPD) is low worldwide. Quantitative computed tomography (QCT) parameters add value to quantify alterations in airway and lung parenchyma for COPD. This study aimed to assess the performance of QCT features in COPD detection using a whole-lung inspiratory CT model. Methods: This multicenter retrospective study was performed on 4106 participants. The derivation cohort containing 1950 participants who enrolled in Guangzhou communities from August 2017 to December 2019, was separated for training and internal validation cohorts, and three external validation cohorts containing 1703 participants were recruited from the public hospitals (Cohort 1: the First Affiliated Hospital of Guangzhou Medical University; Cohort 2: Xiangyang central hospital; Cohort 3: the Second Affiliated Hospital of Xi'an Jiaotong University) in China between April 2017 and May 2024. Questionnaire information, CT reports, and QCT features derived from inspiratory CT were extracted for model development. A novel multimodal framework using eXtreme gradient boosting and hybrid feature selection was established for COPD detection. National Lung Screening Trial (NLST) cohort (n = 453) was applied to validate the multiracial extrapolation and robustness on low-dose CT scans. Findings: The QCT model (referred to as AutoCOPD) with ten features achieved the highest AUC of 0·860 (95% CI: 0·823-0·898) in the internal validation cohort, and showed excellent discrimination when externally validated [Cohort 1: AUC = 0·915 (95% CI: 0·898-0·931); Cohort 2: AUC = 0·903 (95% CI: 0·864-0·943); Cohort 3: AUC = 0·914 (95% CI: 0·882-0·947); NLST: AUC = 0·881 (95% CI: 0·846-0·915)]. Decision curve analysis demonstrated that AutoCOPD was valuable across a range of COPD risk thresholds between 0·12 and 0·66 compared with intervention in all patients with COPD or no intervention. Interpretation: Heterogeneous COPD can be well identified using AutoCOPD (https://lwj-lab.shinyapps.io/autocopd/) constructed by a subset of only ten QCT features. It may be generalizable across clinical settings and serve as a feasible tool for early detecting patients with mild or asymptomatic COPD to reduce delayed diagnosis in routine practice. Funding: The National Natural Science Foundation of China, Guangzhou Laboratory, Natural Science Foundation of Guangdong Province, Guangzhou Municipal Science and Technology grant, State Key Laboratory of Respiratory Disease.

Indexed as

COPDDetectionMachine learningQuantitative computed tomography

Identifiers

PMID40242563
PMCPMC12002883

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