Evidence map›Paper›PMID 40242472›Full record

ArticleFrontiers in genetics2025

Enhanced renal ischemia/reperfusion injury repair potential of exosomes derived from B7-H1

Jiahui He, Yawei Yao, Ruiyan Wang, Yujia Liu, Xingyu Wan, Hao Wang, Yuqiang Zhou, Wenjing Wang, Yan Ma, Xinghua Lv

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiahui HeDepartment of Anaesthesia, The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Yawei YaoDepartment of Anaesthesia, The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Ruiyan WangDepartment of Anaesthesia, The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Yujia LiuDepartment of Anaesthesia, The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Xingyu WanDepartment of Anaesthesia, The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Hao WangDepartment of Day Surgery Center, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Yuqiang ZhouDepartment of Anaesthesia, The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Wenjing WangDepartment of Anaesthesia, The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Yan MaDepartment of Anaesthesia, The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Xinghua LvDepartment of Day Surgery Center, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two subgroups with high expression of B7-H1 and low expression of B7-H1 were successfully isolated from primitive human umbilical cord mesenchymal stem cells. And exosomes with high B7-H1 expression and low B7-H1 expression were successfully isolated. In comparison to the sham-operated group, mice in the IRI group demonstrated elevated serum levels of blood urea nitrogen (BUN) and serum creatinine (Scr), accompanied by a more pronounced degree of renal tissue damage. The administration of exosomes via the tail vein markedly accelerated the recovery of renal function in IRI mice, with the therapeutic effect beingmore pronounced in those treated with B7-H1high-Exo. Moreover RNA sequencing of mouse kidney treated with B7-H1high-Exo and B7-H1low-Exo showed that eight genes (C3, IRF7, AREG, CXCL10, Aldh1l2, Fnip2, Vcam1, St6galnac3) were involved in the pathophysiological process of ischemia-reperfusion injury. The

Indexed as

B7-H1C3cell sortingexosomesNF-κBrenal ischemia-reperfusion injury

Identifiers

PMID40242472
PMCPMC12000007

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.